Comparative Effects of Mechanical and Manual Airway Clearance Techniques in Cystic Fibrosis

Riphah International University

Status: Not yet enrolling

Conditions: Cystic Fibrosis

Treatments: Other: postural drainage with ACBT; Other: flutter with ACBT

Study type: Interventional

Funder types: Other

Identifiers

NCT07062939

REC/RCR & AHS/24/0350

Details and patient eligibility

About

This study will help to establish evidence-based physiotherapy on postural drainage and ACBT against flutter with ACBT is better to improve sleep quality, adherence, dyspnea in patients with cystic fibrosis and which method can improve respiratory function, reduce the risk of complications after illness and additionally advancements in respiratory therapy can lead to improve sleep quality, individual preference and adherence and dyspnea.

Full description

Cystic fibrosis (CF) is a genetic disorder that leads to the accumulation of thick mucus in the lungs and other organs, resulting in recurrent infections and progressive lung damage. This condition is due to mutations in the cystic fibrosis transmembrane conductance regulator CFTR gene, which governs the transport of chloride and other ions across cell membranes. CF affects a significant number of people worldwide, with certain genetic mutations leading to more severe manifestations of the disease. The management of CF is centered on clearing the airways of mucus to prevent infections and slow the progression of lung damage. Various studies have yielded inconsistent results regarding the comparative effectiveness of manual versus mechanical airway clearance techniques in improving pulmonary function tests (PFTs) in CF patients.

Despite the existing literature on postural drainage with ACBT in patient with cystic fibrosis, there is a significant research gap regarding the flutter and ACBT on the bases of outcomes in cystic fibrosis. Most studies have not adequately addressed the distinct needs and responses of flutter with ACBT on the basis of outcomes, leaving a void in understanding how these two intervention effect on sleep, adherence and dyspnea in the context of patients with cystic fibrosis. Closing this gap is essential for developing evidence-based and pulmonary rehabilitation techniques for this specific patient group.

Enrollment: 52 estimated patients

Sex: All

Ages: 16 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient having clinically diagnose Cystic fibrosis.
• Age 16-40 year.
• Both male and female.
• Subjects who are conscious and cooperative .

Exclusion criteria

• Rib fracture
• History of cardiac surgery.
• Subject with any Physical or Mental Disability
• Age less than 16 years

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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52 participants in 2 patient groups

postural drainage with ACBT

Experimental group

Description:

postural drainage and active cycle breathing technique for 2 times a day for 30 min for 4 weeks

Treatment:

Other: postural drainage with ACBT

flutter with ACBT

Active Comparator group

Description:

active cycle breathing technique with flutter for 30 min for 4 week and 2 times a day

Treatment:

Other: flutter with ACBT