Comparative Effects of Nebivolol and Carvedilol on Diastolic Function in the Elderly Heart Failure Patients

Dong-A University

Status: Unknown

Conditions: Heart Failure

Treatments: Drug: Carvedilol; Drug: Nebivolol

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02619526

15-174

Details and patient eligibility

About

Heart failure (HF) is a common and disabling condition in the elderly. Randomized clinical trials and meta-analyses have clearly demonstrated that long-term use of β blockers improves the outcomes of patients with HF. However, limited data have been available on the treatment of HF with preserved ejection fraction (EF) in the elderly. No study has specifically compared the relative effectiveness of carvedilol and nebivolol in treating HF in old age patients with preserved EF.

Full description

This trial is a prospective, randomized, open-label, active controlled study designed to investigate effects of nebivolol and carvedilol on diastolic function of the left ventricle (LV) in the elderly HF patients with preserved EF.

Patients will be included in the study if they had LVEF ≥ 40%, NYHA functional class I, II or III, and clinical stability without hospital admission for HF in the preceding 3 months.

Enrollment: 62 estimated patients

Sex: All

Ages: 70 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• more than 70 years
• EF ≥ 40%

Exclusion criteria

• contraindication to the study drug

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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62 participants in 2 patient groups

Nebivolol

Experimental group

Description:

Nebivolol 10mg, once a day

Treatment:

Drug: Nebivolol

Carvedilol

Active Comparator group

Description:

Carvedilol 25mg, twice a day

Treatment:

Drug: Carvedilol