Comparative Efficacy of 10% Potassium Hydroxide Solution Versus Cryotherapy in Molluscum Contagiosum

Combined Military Hospital Abbottabad

Status and phase: Completed; Phase 1

Conditions: Molluscum Contagiosum

Treatments: Drug: Group A received cryotherpay; Drug: Group B received 10% Potassium Hydroxide Solution

Study type: Interventional

Funder types: Other

Identifiers

NCT05897112

CMHAbbottabad22

Details and patient eligibility

About

A total of sixty patients presented to the outpatient dermatology department of Combined military hospital (CMH) Abbottabad with signs of molluscum contagiosum clinically diagnosed meeting inclusion criteria were enrolled. Sample size was calculated using WHO sample size calculator. They were divided into two groups i.e Group A and Group B using lottery method. Patients in Group A were subjected to cryotherapy (liquid nitrogen gas) whereas patients in Group B patients were subjected to 10% potassium hydroxide solution for 3 weeks and were followed up at 2nd, 4th, 8th and 12th week for observing the progress of therapy in both groups on each follow up visit and ascertaining the efficacy respectively.

Enrollment: 60 patients

Sex: All

Ages: 4 to 12 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of molluscum contagiosum having 3-20 lesion
• no history of treatment before
• willingness to participate (given by parents)

Exclusion criteria

• Patients with facial lesions
• known immunodeficiency
• tendency for hypertrophic scarring
• known hypersensitivity

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Group A received cryotherapy

Active Comparator group

Description:

Group A were subjected to weekly cryotherapy with a cotton stick dip ped in Liquid Nitrogen for 02 Freezes and Thaw Cycle of 07 seconds with each cycle 10 seconds apart for 3 weeks

Treatment:

Drug: Group A received cryotherpay

Group B received 10% Potassium Hydroxide Solution

Active Comparator group

Description:

Group B applied 10% Potassium Hydroxide solution twice daily with the help of a cotton tip applicator until lesion showed signs of inflammation or clearance for 3 weeks

Treatment:

Drug: Group B received 10% Potassium Hydroxide Solution