Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.

University of Health Sciences Lahore

Status and phase: Not yet enrolling; Phase 3

Conditions: Apical Periodontitis; Periapical Radiolucency

Treatments: Drug: Allium Sativum as an intracanal medicament

Study type: Interventional

Funder types: Other

Identifiers

NCT07289971

00/220/22

Details and patient eligibility

About

Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and antimicrobial characteristics. Because conventional medicaments can be expensive or have potential side effects, researchers are actively exploring natural options like garlic. Some lab studies have already shown that garlic gel can kill the microbes inside the teeth. However, no real-life clinical or X-ray studies have been done on using garlic in permanent teeth. This study may help scientists find a much safer and effective new material for dental treatments in the future.

Full description

Clinical trials are needed to evaluate the effectiveness of Allium sativum as an intracanal medicament due to its various useful properties, such as anti-inflammatory, wound healing action, and antimicrobial properties. To overcome the problems with synthetic medicament, researchers are looking for natural alternatives due to their low cost, easy availability, and safety. The objective of the study is to evaluate and compare the clinical and radiographic treatment outcomes of using garlic gel and calcium hydroxide paste as an intracanal medicament in nonsurgical root canal treatment of permanent teeth in terms of:

• Pain.
• Tenderness to palpation.
• Tenderness to percussion.
• Size of Periapical radiolucency.

Enrollment: 96 estimated patients

Sex: All

Ages: 15 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with the physical status of ASA I and ASA II according to ASA classification.
• Patients aged from 15-45 years.
• Mature permanent single-rooted teeth with closed apices.
• Patients with clinical signs of symptomatic apical periodontitis (pain, tenderness to palpation, and percussion).
• Patients having radiographic evidence of periapical radiolucency of endodontic origin.
• Patients who have not taken antibiotics for the past 14 days.
• Cooperative patients who show good compliance.

Exclusion criteria

• Patients with physical status of ASA III, IV, and V according to ASA classification.
• Teeth with a calcified pulp chamber in periapical radiography.
• Patients who have undergone previous endodontic treatment failure and those with the presence of sinus tract on clinical examination.
• Teeth having advanced periodontal disease, with the basic periodontal examination (BPE) of 3 and 4.
• Presence of internal and external resorption of the root as viewed on the periapical radiograph.
• Presence of vertical root fracture and perforation as viewed on the periapical radiograph

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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96 participants in 2 patient groups

Experimental group(n=48)

Experimental group

Description:

Garlic gel will be used as an intracanal medicament

Treatment:

Drug: Allium Sativum as an intracanal medicament

Control group(n=48)

Active Comparator group

Description:

Patients will receive informed consent, clinical exam, and preoperative radiographs. After anesthesia and rubber dam isolation, access, cleaning, and shaping of canals will be performed using standard endodontic techniques. Calcium hydroxide (control) will be placed as intracanal medicament, followed by temporary restoration of Cavit and Glass Ionomer cement. After 14 days, if clinical symptoms of pain, tenderness to palpation and percussion resolve, the medicament will be removed, and the canal will be obturated and permanently restored. However, if the patient remains clinically symptomatic, then another dressing of calcium hydroxide will be placed. Finally, clinical outcomes will be recorded after a month and obturation will be delayed until the complete resolution of clinical signs and symptoms. Patients will return after 6 months for clinical and radiographic evaluation, with pre- and postoperative radiographs compared by two endodontists.

Treatment:

Drug: Allium Sativum as an intracanal medicament