Comparative Evaluation of the Effect of Different Adjunctive Air Polishing Powders in Nonsurgical Periodontal Therapy in Patients with Stage II and III Periodontitis (GBT)

Diana Ibrahim

Status: Invitation-only

Conditions: Periodontitis

Treatments: Other: SRP and SI; Other: GBT and SI with glycine powder; Other: GBT and SI with trehalose powder; Device: GBT and SI with erythritol powder

Study type: Interventional

Funder types: Other

Identifiers

NCT06726902

IORG 0008839-0854-01/2024

Details and patient eligibility

About

The aim of this clinical trial is to evaluate and compare the effect of a newly designed air-polishing device (APD) using Erythritol, Glycine, and Trehalose air-polishing powders in nonsurgical periodontal therapy with control (conventional scaling and root planning) following the concept of guided biofilm therapy (GBT) as an adjunctive to subgingival instrumentation (SI) in nonsurgical periodontal therapy for Stage II and III periodontitis patients both clinically and microbiologically.

Enrollment: 56 estimated patients

Sex: All

Ages: 30 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Individuals of both sexes with an age between 30 and 65 years, having at least 16 natural teeth in function,
2. Stage II and III (moderate to severe) periodontitis, having at least 16 teeth with the need for SI
3. Interproximal plaque index (API) ≤ 35%; patients with Good oral hygiene.
4. No history of systemic disease that may influence periodontal disease

Exclusion criteria

1. Pregnancy or breastfeeding,
2. Smokers with more than seven cigarettes per day
3. Patients that had a treatment with antibiotics within six months before the study
4. Need for periodontal surgery or adjunctive antibiotic treatment to the SI
5. Patients who had any periodontal treatment during the last year before the study.
6. Patients with known systemic or autoimmune disease.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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56 participants in 4 patient groups

Test Group I (GBT and SI + erythritol powder)

Experimental group

Description:

will receive GBT and SI with adjunctive air-polishing using Standard/ Subgingival nozzle + erythritol powder

Treatment:

Device: GBT and SI with erythritol powder

Test Group II (GBT and SI + glycine powder)

Experimental group

Description:

will receive GBT and SI with adjunctive air-polishing using Standard/ Subgingival nozzle + glycine powder

Treatment:

Other: GBT and SI with glycine powder

Test Group III (GBT and SI + Trehalose powder)

Experimental group

Description:

will receive GBT and SI with adjunctive air-polishing using Standard/ Subgingival nozzle + Trehalose powder

Treatment:

Other: GBT and SI with trehalose powder

Control Group VI (SRP and SI)

Experimental group

Description:

will receive conventional Scaling and Root planning (SRP) and (SI) without adjunctive air polishing powder

Treatment:

Other: SRP and SI