Comparative Evaluation of the Effect of Prophylactic Intraligamentary Injection of Dexamethasone and Piroxicam on Postoperative Pain in Teeth With Symptomatic Irreversible Pulpitis

Cairo University (CU)

Status: Unknown

Conditions: Postoperative Pain

Treatments: Drug: Mepivacaine HCL; Drug: Dexamethasone sodium phosphate; Drug: Piroxicam Injectable Solution

Study type: Interventional

Funder types: Other

Identifiers

NCT03745105

CEBD-CU-2018-11-01

Details and patient eligibility

About

the study is conducted to assess and compare the efficacy of local intraligamentary injection of glucocorticoids(dexamethasone) and NSAID(piroxicam) on reduction of postoperative pain in patients with symptomatic irreversible pulpitis.

Enrollment: 42 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Systemically healthy patient (ASA I or II).

2. Mandibular Posterior teeth with:

   • Preoperative sharp pain.
   • Absence of widening in the periodontal ligament (PDL).
   • Vital response of pulp tissue to cold pulp tester (ethyl chloride spray).

Exclusion criteria

1. Patients allergic to anesthetics, piroxicam (any other NSAIDs) or dexamethasone (other corticosteroids).
2. Pregnant or nursing females.
3. Patients having significant systemic disorder (ASA III or IV).
4. Hemostatic disorders or anti-coagulant therapy during the last month.
5. Consumption of opioid or non-opioid analgesics or corticosteroids during the last 12 hrs before treatment.
6. Retreatment cases.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

42 participants in 3 patient groups

dexamethasone

Experimental group

Description:

Pretreatment intraligamentary injection of 0.4 mL of 8 mg/2 mL dexamethasone (Dexamethasone, AMRIYA pharmaceutical, Egypt)

Treatment:

Drug: Dexamethasone sodium phosphate

piroxicam

Experimental group

Description:

Pretreatment intraligamentary injection of 0.4 mL of 20 mg mL-1 piroxicam (Feldene, Pfizer, Egypt)

Treatment:

Drug: Piroxicam Injectable Solution

Mepivacaine HCL

Active Comparator group

Description:

Pretreatment Intraligamentary injection of 0.4 mL of Mepivacaine HCl 36 mg /1.8 ml + Levonordefrin HCl 0.108 mg/ 1.8 ml (Mepecaine - L, Alexandria Co.-Egypt)

Treatment:

Drug: Mepivacaine HCL