Comparative Exercise-Induced Hypoalgesia in Upper and Lower Limbs: A Randomized Controlled Trial in Healthy Individuals

Centro Universitario La Salle

Status and phase: Enrolling; Phase 1

Conditions: Healthy Subjects

Treatments: Other: Aerobic exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT06283186

CSEULS-PI-004/2024

Details and patient eligibility

About

This randomized controlled trial with healthy subjects aims to compare exercise-induced hypoalgesia among three groups: one utilizing a lower limb cycle ergometer, another using an upper limb cycle ergometer, and a control group. The exercise protocol involves 30 minutes of aerobic activity at 70-80% of the heart rate reserve. Exercise-induced hypoalgesia will be assessed by measuring pressure pain thresholds in the thigh and elbow. Additionally, a secondary objective is to compare the lower limb and upper limb cycle ergometer groups in terms of their effects on pressure pain thresholds in the thigh and elbow. Thus, the study anticipates observing differences in local and distal hypoalgesia based on the trained region.

Enrollment: 90 estimated patients

Sex: All

Ages: 18 to 64 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Asymptomatic subjects aged between 18 and 64 years.

Exclusion criteria

• Cardiovascular, respiratory, metabolic, neurological, or osteomuscular signs or pathologies.
• History of epilepsy.
• Pregnant
• Pharmacological treatment.
• Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 12 weeks.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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90 participants in 3 patient groups

Lower limb cycle ergometer

Experimental group

Description:

The participants in the lower limb cycle ergometer group will undergo a 30-minute aerobic exercise intervention comprising a 5-minute warm-up, 20 minutes of training at 70-80% of the heart rate reserve, and a 5-minute cool-down.

Treatment:

Other: Aerobic exercise

Other: Aerobic exercise

Upper limb cycle ergometer

Experimental group

Description:

The participants in the upper limb cycle ergometer group will undergo a 30-minute aerobic exercise intervention comprising a 5-minute warm-up, 20 minutes of training at 70-80% of the heart rate reserve, and a 5-minute cool-down.

Treatment:

Other: Aerobic exercise

Other: Aerobic exercise

Control

No Intervention group

Description:

Participants in the control group will remain seated for the entire 30-minute duration of the experiment without receiving any form of distraction.