Comparative Factorial Study Design of Ultrasound Guided Wrist Block for Hand Surgery Comparing Effect of Bupivacane Alone and Bupivacane with Dexamethasone and Bupivacane with Dexametmiodine and Bupivacane with Dexamethasone and Dexametmiodine

Mahmoud Rafaat Mohamed

Status and phase: Enrolling; Phase 4

Conditions: Hand Surgeries

Treatments: Procedure: Group 1: ultrasound guided wrist block with bupivacane alone; Procedure: Group 4: patients will receive ultrasound guided wrist block with bupivacane and dexamethasone and dexametmiodine; Procedure: Group 2 : ultrasound guided wrist block with bupivacane and dexamethasone; Procedure: Group 3: ultrasound guided wrist block with bupivacane and dexametmiodine

Study type: Interventional

Funder types: Other

Identifiers

NCT06826690

963-9-24

Details and patient eligibility

About

Ultrasound guided wrist block comparing effect of bupivacane alone and bupivacane with dexamethasone and bupivacane with dexametmiodine and bupivacane with dexamethasone and dexametmiodine

Full description

Ultrasound guided wrist block comparing effect of bupivacane alone and bupivacane with dexamethasone and bupivacane with dexametmiodine and bupivacane with dexametmiodine and dexamethasone.

Taking medical and surgical history from patients. Taking base line data as heart rate and blood pressure and spo2. Measure duration of analgesia for post operative pain using NRS for 24 hours abd recording NRS at time interval of 2 , 4,6,12,24 hours post operative.

Any patient the NRS above 4 will receive 5 mg nalbufin . Recording patients satisfaction by a survey .

Enrollment: 160 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients more than or equal 18 years old and are ASA 1-3

Exclusion criteria

• allergy to used medication
• pre exist neuropathy
• coagulapthy
• cognitive impairment
• refusal to participate
• Failed block and requiring general anesthesia

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Factorial Assignment

Masking: None (Open label)

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160 participants in 4 patient groups

Group 1: ultrasound guided wrist block with bupivacane alone

Active Comparator group

Description:

Group 1: ultrasound guided wrist block with bupivacane.025% .. 15 ml volume totally

Group2: ultrasound guided wrist block with bupivacane.25% and 8mg dexamethasone

Active Comparator group

Description:

Group 2: 40 patients receive ultrasound guided wrist block with 15 ml volume including bupivacane.25% and 8 mg dexamethasone

Group 3: ultrasound guided wrist block with bupivacane and dexametmiodine

Active Comparator group

Description:

Group 3: 40 patients receive ultrasound guided wrist block with 15 ml volume totally including bupivacane.25% and 50 mcg dexametmiodine

Group 4: ultrasound guided wrist block with bupivacane and dexametmiodine and dexamethasone

Active Comparator group

Description:

Group 4 : 40 patients receive ultrasound guided wrist block with 15 ml volume including bupivacane.25% and 8 mg dexamethasone and 50 mcg dexametmiodine