Comparative Microarray Analysis in Primary Cutaneous Malignant Melanoma

Ruhr University of Bochum

Status: Completed

Conditions: Cutaneous Malignant Melanoma

Treatments: Procedure: Biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT01482260

microRNA5

Details and patient eligibility

About

Perturbations in microRNA (miRNA) expression profiles has been reported for cutaneous malignant melanoma (CMM). This study will be an exploratory analysis by miRNA expression profiling using microarrays.

Full description

Perturbations in microRNA (miRNA) expression profiles has been reported for cutaneous malignant melanoma (CMM). With regards to a rapidly growing number of newly discovered miRNA sequences, the availability of up-to-date miRNA expression profiles for primary cutaneous malignant melanoma (PCMM), cutaneous malignant melanoma metastases (CMMM) and benign melanocytic naevi (BMN) is limited. Patients with PCMM, CMMM and BMN are included in the study to perform an exploratory analysis by miRNA expression profiling using microarrays. Expression levels of miRNA candidates will be validated by TaqMan real-time quantitative polymerase chain reaction (RT-PCR).

Enrollment: 21 patients

Sex: All

Ages: 1+ year old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Primary Cutaneous Malignant Melanoma
• Cutaneous Malignant Melanoma Metastases
• Benign Melanocytic Naevi

Exclusion criteria

• Other Skin Cancer than Primary Cutaneous Malignant Melanoma

Trial design

21 participants in 3 patient groups

Primary Cutaneous Malignant Melanoma

Treatment:

Procedure: Biopsy

Cutaneous Malignant Melanoma Metastases

Treatment:

Procedure: Biopsy

Benign Melanocytic Nevi

Treatment:

Procedure: Biopsy