Comparative Pain Control Between 0.2 or 0.3 Spinal Morphine and 0.25 or 0.5 % Bupivacaine for FNB After TKA

Mahidol University

Status and phase: Completed; Phase 4

Conditions: Total Knee Replacement; Post Operative Pain

Treatments: Drug: morphine and bupivacaine; Drug: spinal morphine and marcaine

Study type: Interventional

Funder types: Other

Identifiers

NCT00795223

461/2551(EC1)

Grant by the siriraj Hospital

Details and patient eligibility

About

Comparative efficacy of 24 and 48 hours post operative pain control in single total knee replacement between intrathecal bupivacaine with 0.2 or 0.3 mg morphine together with 0.25 or 0.5 % bupivacaine for single femoral nerve block

Enrollment: 160 patients

Sex: All

Ages: 45 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Single elective total knee replacement in ASA 1-3 without significant cardiovascular limitation

Exclusion criteria

• patient at risk in usage COX-2 for post operative pain control

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

160 participants in 4 patient groups

1

Active Comparator group

Description:

Injection of 0.3 mg morphine with spinal block and perform femoral nerve block with 0.5% bupivacaine

Treatment:

Drug: morphine and bupivacaine

Drug: morphine and bupivacaine

Drug: morphine and bupivacaine

2

Active Comparator group

Description:

Injection of 0.3 mg morphine with spinal block and perform femoral nerve block with 0.25% bupivacaine

Treatment:

Drug: spinal morphine and marcaine

3

Active Comparator group

Description:

Injection of 0.2 mg morphine with spinal block and perform femoral nerve block with 0.5% bupivacaine

Treatment:

Drug: morphine and bupivacaine

Drug: morphine and bupivacaine

Drug: morphine and bupivacaine

4

Active Comparator group

Description:

Injection of 0.2 mg morphine with spinal block and perform femoral nerve block with 0.25% bupivacaine

Treatment:

Drug: morphine and bupivacaine

Drug: morphine and bupivacaine

Drug: morphine and bupivacaine