Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder

Mental Health Services in the Capital Region, Denmark

Status: Completed

Conditions: Major Depressive Disorder

Treatments: Drug: Antidepressant

Study type: Observational

Funder types: Other

Identifiers

NCT05952713

MHSCRDenmark_2

Details and patient eligibility

About

Achieving results from RCTs with high internal and external validity is a major challenge within psychiatry due to the nature of psychiatric illnesses. The Investigators will conduct a "real world" naturalistic nation-wide population-based longitudinal register linkage study comparing long-term responses to all kinds of antidepressants in patients with major depressive disorder emulating a randomized trial.

Enrollment: 73,336 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

All patients with a psychiatric contact (as inpatients or outpatients) in the period from 1995 to 2018 with a first main index diagnosis of a single depressive episode or recurrent depressive disorder (ICD-10 code: F32-F33.9) with an outpatient purchase of an antidepressant after the depression diagnosis (N=73.336).

Exclusion criteria

None.

Trial design

73,336 participants in 6 patient groups

SSRI

Description:

Group 1: Selective serotonin reuptake inhibitors (reference: sertraline) Comparisons of the following with sertraline: Citalopram, Fluoxetine, Paroxetine, Escitalopram

Treatment:

Drug: Antidepressant

NARI

Description:

Group 2: Noradrenaline reuptake inhibitors (reference: sertraline) Comparisons of the following with sertraline: Reboxetine

Treatment:

Drug: Antidepressant

SNRI

Description:

Group 3: Serotonin and noradrenaline reuptake inhibitors (reference: venlafaxine) Comparisons of Duloxetine with venlafaxine

Treatment:

Drug: Antidepressant

ARI

Description:

Group 4: Adrenergic receptor inhibitors (reference: Mirtazapine) Comparisons of Mianserin with Mirtazapine

Treatment:

Drug: Antidepressant

Other drugs

Description:

Group 5: Other drugs (reference: sertraline) Comparisons of Vortioxetine and Agomelatine with sertraline

Treatment:

Drug: Antidepressant

TCA

Description:

Group 6: Tricyclic antidepressants (reference: amitriptyline) Comparisons of Nortriptyline, Imipramine, Clomipramine and Dosulepin with amitriptyline

Treatment:

Drug: Antidepressant