Comparative Study Between Oxytocin Infusion Before and After Placental Delivery on Blood Loss During and After Cesarean Delivery .

Cairo University (CU)

Status: Completed

Conditions: Intraoperative Blood Loss

Treatments: Drug: Oxytocin

Study type: Interventional

Funder types: Other

Identifiers

NCT06889155

110

Details and patient eligibility

About

Participants were randomized using computer-generated random numbers into 2 groups. Group I included 32 women who received oxytocin infusion before placental delivery just after cord clamping and group II included 32 women who received oxytocin infusion after placental delivery. In both groups 10 IU of oxytocin (Syntocinon, Novartis, Basel, Switzerland) were diluted in 500 mL of normal saline and administered through intravenous infusion over 30 minutes.

Full description

Participants were randomized using computer-generated random numbers into 2 groups. Group I included 32 women who received oxytocin infusion before placental delivery just after cord clamping and group II included 32 women who received oxytocin infusion after placental delivery. In both groups 10 IU of oxytocin (Syntocinon, Novartis, Basel, Switzerland) were diluted in 500 mL of normal saline and administered through intravenous infusion over 30 minutes.

Enrollment: 64 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 18 - 40 years
• singleton full term pregnancy.
• Candidate for elective cesarean delivery under spinal anaesthesia

Exclusion criteria

• women at high risk for intraoperative bleeding as those with placenta previa or other placental abnormalities
• women with bleeding or coagulation disorders.
• Medical disorder associating pregnancy as preeclampsia or diabetes
• Allergy or contraindications to oxytocin
• Fetal macrosomia, or congenital anomalies
• Polyhydramnios
• Uterine abnormalities as fibroids
• Women with intraoperative complications as vascular or visceral injuries

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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64 participants in 2 patient groups

oxytocin before placental delivery

Active Comparator group

Description:

oxytocin infusion before placental delivery just after cord clamping 10 IU of oxytocin (Syntocinon, Novartis, Basel, Switzerland) were diluted in 500 mL of normal saline and administered through intravenous infusion over 30 minutes.

Treatment:

Drug: Oxytocin

oxytocin after placental delivery

Active Comparator group

Description:

oxytocin infusion after placental delivery 10 IU of oxytocin (Syntocinon, Novartis, Basel, Switzerland) were diluted in 500 mL of normal saline and administered through intravenous infusion over 30 minutes.

Treatment:

Drug: Oxytocin