Comparative Study Between Platelet Rich Plasma and Steroid Injection in Trigger Finger Treatment

Obafemi Awolowo University Teaching Hospital

Status and phase: Not yet enrolling; Phase 3

Conditions: Trigger Finger Disorder

Treatments: Drug: Pfizer Depo-medrol; Biological: Platelet rich plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT06532318

ERC/2024/06/12

Details and patient eligibility

About

The goal of this clinical trial is to learn if platelet rich plasma works to treat early stage trigger finger in adults. It will also learn about the safety platelet rich plasma. The main questions it aims to answer are:

Does platelet rich plasma lower the pain associated with trigger finger of participants? Does it improve the hand grip strength and Q DASH score of participants? Researchers will compare platelet rich plasma to Depo-Medrol steroid (a known standard of care for early stage trigger finger) to see if platelet rich plasma works to treat early trigger finger.

Participants will:

Take platelet rich plasma or a depo-medrol steroid intralesional injection at recruitment into the intervention Visit the clinic once every 4 weeks for checkups and parameter measurements. Investigator will will keep a record of participants progress in symptom remission

Enrollment: 40 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who are 18year and above with mild or moderate trigger finger, who are willing to have intra-lesional administration of blood product.

No previous treatment for the affected finger.

Exclusion criteria

• Previous steroid injection
• Previous Surgery to that finger
• Thrombocytopenic patients
• Hand and finger contracture
• Rheumatoid arthritis of the finger

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Group A

Experimental group

Description:

Patients here will have one milliliter of freshly prepared autologus platelet rich plasma injection for the treatment of their trigger finger.

Treatment:

Biological: Platelet rich plasma

Group B

Active Comparator group

Description:

Patients here will have one milliliter(20mg) injection of pfizer Depo-medrol(methylprednisolone acetate) injection for the treatment of their trigger finger.

Treatment:

Drug: Pfizer Depo-medrol