Comparative Study for Treatment of Alopecia Areata Using Carboxytherapy and Intralesional Steroids

Kasr El Aini Hospital

Status and phase: Unknown; Phase 4

Conditions: Alopecia Areata

Treatments: Device: Carboxytherapy; Drug: Intralesional Steroid Injection

Study type: Interventional

Funder types: Other

Identifiers

NCT04228029

KasrEliniH

Details and patient eligibility

About

Patients with three lesions of alopecia areata are randomly recruited in this study. Each lesion is randomized in to receiving either carboxytherapy in one lesion, intralesional steroids in another lesion and combination of both in the third lesion.

Treatment period is 3 months followed by a follow-up period of 2 months.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• early localized scalp alopecia areata
• patients who did not receive any medication for at least 2 months before starting the study Patients who agreed to join the study and signed written consent.

Exclusion criteria

• pregnant, and lactating females and those with unrealistic expectation.
• Alopecia totalis or universalis or ophiasis or cicatrising alopecia
• Usage of systemic treatment of alopecia areata 2 months prior to the study.
• Any scalp lesion within the treated area
• Bleeding diathesis, severe anemia or platelet disorders
• Medical conditions such as autoimmune diseases.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Sequential Assignment

Masking: Double Blind

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30 participants in 3 patient groups

Carboxytherapy

Active Comparator group

Treatment:

Device: Carboxytherapy

Intralesional steroids

Active Comparator group

Treatment:

Drug: Intralesional Steroid Injection

Combination of carboxytherapy and intralesional steroids

Active Comparator group

Treatment:

Drug: Intralesional Steroid Injection

Device: Carboxytherapy