Comparative Study of Autologous Blood Injection Versus Diluted Epinephrine in Treating Actively Bleeding Gastroduodenal Ulcers

Zagazig University

Status: Completed

Conditions: Blood, Injection, Injury Type Phobia; Gastrointestinal Ulcer Haemorrhage; Adverse Reaction to Epinephrine

Treatments: Biological: Blood; Drug: Epinephrine

Study type: Interventional

Funder types: Other

Identifiers

NCT01560702

IRB#:278/12-3-2012

Details and patient eligibility

About

Endoscopic injection of autologous blood can control bleeding from gastroduodenal ulcers.

Full description

To test the hypothesis that endoscopic injection of autologous blood is superior to endoscopic injection of diluted epinephrine in controlling bleeding from gastroduodenal ulcers.

Enrollment: 100 patients

Sex: All

Ages: 16 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all adult patients with gastroduodenal ulcer

Exclusion criteria

• Patients with non ulcer bleeding.
• Patients with malignancy.
• Patients with bleeding disorders or under coagulation therapy.
• Patients with known allergy to epinephrine.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Autologous blood

Active Comparator group

Description:

Patients will be injected by autologous blood at the edge of actively bleeding ulcer

Treatment:

Biological: Blood

Epinephrine injection

Other group

Description:

Patients will be injected by diluted epinephrine at the edge of actively bleeding ulcer

Treatment:

Drug: Epinephrine