Comparative Study of Gender Identity Disorder Versus Control (TRANSIDENT)

Centre Hospitalier Henri Laborit

Status: Enrolling

Conditions: Gender Dysphoria, Adult

Treatments: Other: Psychiatric evaluations

Study type: Observational

Funder types: Other

Identifiers

NCT04935164

2020-A03407-32

Details and patient eligibility

About

Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity.

Full description

Gender dysphoria is manifested by an internal tension between biological sex and gender, that is, by a non-congruence, in the subjects who suffer from it, between their sex of birth and their social gender identity. Gender dysphoria is accompanied by the often overwhelming need for a hormonal or even hormone-surgical transition. Gender dysphoria is very often characterized by fluctuating mood sadness, irritability, obsessionality. An improvement in the quality of life after medical treatment (hormone therapy) and gender reassignment surgery has been described in the literature. Morphological similarities have been found between the brains of women and the brains of so-called transgender women, as well as between the brains of transgender men and men. These morphological data are only very fragmentary and have not been supported by neuro-functional data. Self-awareness, which refers to the awareness that an individual has of his body, his image and his own identity, is partly underpinned, at the brain level, by the activation of the Default Mode Network (DMN) at rest, in non-pathological conditions. The conflict between the internal perception of the own body and its objective representation could result in a change in brain connectivity within the DMN, due in particular to changes in the activation of the temporo parietal junction.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with gender dysphoria
• Without psychotropic
• Without hormono-therapy
• Without sexual surgery assignation

Exclusion criteria

• Any depression
• Any addiction

Trial design

120 participants in 4 patient groups

Male patients with gender dysphoria

Description:

* male patients with gender dysphoria according to DSM-V criteria (axis I), confirmed by MINI evaluation * patients without psychotropic treatments * patients who do not benefit of hormone therapy * patients who have not yet received gender reassignment surgery * patients aged 18 to 60 years * patients with normal or corrected vision * patients without mental defect * patients without neurological impairment

Treatment:

Other: Psychiatric evaluations

Female patients with gender dysphoria

Description:

* female patients with gender dysphoria according to DSM-V criteria (axis I), confirmed by MINI evaluation * patients without psychotropic treatments * patients who do not benefit of hormone therapy * patients who have not yet received gender reassignment surgery * patients aged 18 to 60 years * patients with normal or corrected vision * patients without mental defect * patients without neurological impairment

Treatment:

Other: Psychiatric evaluations

Male volunteers without gender dysphoria

Description:

* male volunteer without gender dysphoria according to DSM-V criteria (axis I), confirmed by MINI evaluation * volunteer aged 18 to 60 years * volunteer with normal or corrected vision * volunteer without mental defect * volunteer without neurological impairment

Treatment:

Other: Psychiatric evaluations

Female volunteers without gender dysphoria

Description:

* female volunteer without gender dysphoria according to DSM-V criteria (axis I), confirmed by MINI evaluation * volunteer aged 18 to 60 years * volunteer with normal or corrected vision * volunteer without mental defect * volunteer without neurological impairment

Treatment:

Other: Psychiatric evaluations