Comparative Study of Metformin Versus Doxycycline in Moderate to Severe Adult Acne Vulgaris Patients.

Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Status and phase: Enrolling; Phase 2

Conditions: Acne Vulgaris

Treatments: Drug: Metformin and doxycycline

Study type: Interventional

Funder types: Other

Identifiers

NCT06252194

BSMMU/2022/11379

Details and patient eligibility

About

The goal of this clinical trial is to compare the effect of doxycycline and metformin in treatment of acne vulgaris patients. The main question is aimed to answer is whether metformin is more effective than doxycycline in treatment of acne vulgaris patient or not.

Patients will be asked to take doxycycline along with tropical treatment in one group and metformin along with tropical treatment in another group.

Researcher will compare the clinical improvement in two groups.

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Newly diagnosed moderate and severe AV patients diagnosed by a dermatologist

Exclusion criteria

• Patients receiving topical retinoids within last two months
• Pregnancy and lactation
• History of corticosteroids intake
• Suffering from malignancy or any cosmetic induced acne

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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120 participants in 2 patient groups

Group A

Experimental group

Description:

Metformin 500 mg twice daily along with topical retinoids for 12 weeks

Treatment:

Drug: Metformin and doxycycline

Group B

Active Comparator group

Description:

Doxycycline 100 mg twice daily along with topical retinoids for 12 weeks

Treatment:

Drug: Metformin and doxycycline