Comparative Study of microRNA Changes in Patients With Reactive Lymphoid Hyperplasia and Malignant Lymphoma

University of Electronic Science and Technology of China

Status: Unknown

Conditions: Hyperplasia Lymphoid Reactive; Lymphoma

Study type: Observational

Funder types: Other

Identifiers

NCT03167476

Uestc502

Details and patient eligibility

About

The objectives are to:

1. validate a panel of tissue-specific miRNAs that are differentially expressed in the tissue of patients with and without reactive hyperplasia and lymphoma.
2. investigate the physiological range of the miRNA panel in lymphoma and reactive hyperplasia subjects.
3. investigate the dysregulation of miRNA panel and their prognostic and predictive values in clinical outcomes to identifying patients with malignant lymphoma or reactive hyperplasia.

The objectives are to:

1. validate a panel of tissue-specific miRNAs that are differentially expressed in the tissue of patients with and without reactive hyperplasia and lymphoma.
2. investigate the physiological range of the miRNA panel in lymphoma and reactive hyperplasia subjects.
3. investigate the dysregulation of miRNA panel and their prognostic and predictive values in clinical outcomes to identifying patients with malignant lymphoma or reactive hyperplasia.

This trial involves tissue samples diagnosed as lymphoma and reactive hyperplasia. The investigators will develop panels of miRNAs that are specific biomarkers of lymphoma, and assist clinical outcomes with these miRNAs.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults 18 years and above
• Has condition related to lymphoma or reactive lymphoid hyperplasia

Exclusion criteria

• Age below 18 years
• Known pregnancy
• lymph tissue cannot be accessed

Trial design

200 participants in 2 patient groups

RLH

Description:

This group includes subjects diagnosed with reactive lymphoid hyperplasia.

Lymphoma

Description:

This group includes subjects diagnosed with lymphoma.