Comparative Study of Muc5ac and Muc2 Mucins in Tear Film Concentration in Surgical Treated Pterygia Patients

Instituto de Oftalmología Fundación Conde de Valenciana

Status: Completed

Conditions: Pterygium of Both Eyes

Treatments: Procedure: Amniotic membrane transplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT04385446

CC-001/105

Details and patient eligibility

About

To identify and compare the differences in the concentration of the Muc2 and Muc5AC mucins in tear film in patients who underwent pterygium surgery using amniotic membrane transplantation and conjunctival autograft surgery.

Full description

Patients with nasal, primary pterygium bigger than 1 mm of corneal invasion with residence in Mexico City and older than 18 years were included. Under informed consent, patients were divided into two groups in a random fashion. Pterygium surgery was carried out with conventional technique performing amniotic membrane transplantation for group A, and conjunctival autograft for group B. Muc2 and muc5ac mucin concentration was measure min tear film by ELISA; samples were taken before surgery, at first, third and sixth month postoperatively. BUT was also measured on the same dates. Descriptive statistics and the U-Mann Whitney test for independent groups, considering a p≤0.05 as significant were used for analysis.

Enrollment: 44 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with nasal, primary pterygium bigger than 1 mm.

Exclusion criteria

• Diabetes mellitus, single eye.

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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44 participants in 2 patient groups

Amniotic membrane transplantation

Active Comparator group

Description:

Amniotic membrane transplantation was used as covering material in the area where the pterygium tissue was removed during the surgery.

Treatment:

Procedure: Amniotic membrane transplantation

conjnctival autograft.

No Intervention group

Description:

Conjunctival autograft was used as a covering material in the area where the pterygium tissue was removed during the surgery.