Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors

Peking University

Status: Invitation-only

Conditions: Adrenal Tumor; Cushing s Syndrome; Pheochromocytoma/Paraganglioma (PPGL); Primary Aldosteronism

Study type: Observational

Funder types: Other

Identifiers

NCT07182175

2024yan411-002

Details and patient eligibility

About

The main goal of this study is to follow patients with functional adrenal tumors during the time before and after their surgery.

The main questions it aims to answer are:

• What heart and blood pressure changes do patients with different types of adrenal tumors have before surgery?
• What factors affect how the heart and blood pressure recover after surgery?
• Do the heart and blood pressure conditions before surgery influence recovery and the risk of heart or brain problems after surgery?

Patients will have heart ultrasound checks and health monitoring before and after surgery. The results will help doctors choose the right medicines before surgery, better understand possible risks during the operation, and make safer treatment plans for patients with functional adrenal tumors.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients diagnosed in the Department of Urology, Peking University First Hospital with pheochromocytoma and paraganglioma (PPGL), primary aldosteronism (PA), or Cushing syndrome (CS);
• Written informed consent obtained.

Exclusion criteria

• Patients with PPGL, PA, or CS who receive medication or conservative treatment and are not eligible for surgical resection;
• Patients with communication disorders or severe physical impairments such as aphasia, or visual/hearing disabilities;
• Patients with severe mental illness who cannot cooperate with the study;
• Pregnant women or patients otherwise deemed unsuitable for participation by the investigators.

Trial design

150 participants in 3 patient groups

primary aldosteronism

Cushing s Syndrome

Pheochromocytoma/Paraganglioma (PPGL)