Compare Diagnostic Performance of DIXON &CHESS Sequences Calculating RAMRIS Score in Early Rheumatoid Arthritis. (IDEAL PR)

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Completed

Conditions: Arthritis, Rheumatoid

Treatments: Diagnostic Test: Dixon sequences acquisition

Study type: Interventional

Funder types: Other

Identifiers

NCT03943563

2016/24FEV/069 (Other Identifier)

Ideal PR

Details and patient eligibility

About

In a preliminary MRI study of healthy volunteers's hands investigators showed that the suppression of the fat signal obtained by the Dixon sequences is greater than that obtained by the "classic" CHESS sequences with a better T1-weighted image quality. The investigators goal now is to compare these sequences in the quantification of the inflammatory activity of rheumatoid arthritis by the RAMRIS score. To investigators knowledge, only one study compared those two types of sequence with many limitations including a limited number of patients included.

Full description

Rheumatoid arthritis (RA) is the most common chronic inflammatory arthropathy and it mostly affect young women. The MRI sequences currently validated for the joint inflammation assessment are the fat-suppressed sequences produced either by spectral presaturation (CHESS sequences) or by inversion-recovery (STIR = short tau inversion recovery sequence). The presaturation sequences outweigh the STIR sequence due to higher spatial resolution at the expense of sometimes more random saturation of the fat signal. Recently, a third method of suppressing the fat signal (Dixon method) has reappeared thanks to advances in computing power (post-processing). In a preliminary MRI study of the hands of healthy volunteers, the investigators showed that the suppression of the fat signal obtained by the Dixon sequences is greater than that obtained by the "classic" CHESS sequences in T1 and T2 weighting with better quality. image in T1 weighting. This increased performance, particularly in terms of fat suppression, could lead to better detection of PR lesions on MRI.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• • Rheumatoid arthritis diagnosis for less than 3 years

Exclusion criteria

• contraindication to Dotarem contrast injection
• contraindication to MRI due to incompatible implanted material (peacemaker, prosthesis,...)

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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60 participants in 1 patient group

single cohort

Other group

Description:

There is only one cohort where each patient experiment the "classic sequences" as the standard of care and the DIXON sequences for the study.

Treatment:

Diagnostic Test: Dixon sequences acquisition