Compare Effects of Flax Seed Oil, and Fish Oil on Blood Sugar Levels (PCOS)

University of California (UC) Davis

Status: Completed

Conditions: Polycystic Ovarian Syndrome

Treatments: Dietary Supplement: Soybean Oil; Dietary Supplement: Fish Oil; Dietary Supplement: Flax Seed Oil

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT00579540

200715060

Details and patient eligibility

About

Flax seed oil, fish oil, and soy bean oil, are commonly recommended supplements for Polycystic Ovarian Syndrome (PCOS). These oils have different chemical structures and biological actions. It is not yet known which of these oils has the most beneficial effects in PCOS patients because they have never been compared to each other head to head. In this study the researchers hope to learn more about the effects of these oils on blood sugar and insulin levels.

Full description

The aim is to investigate whether n-3 PUFA's can be used to prevent postprandial hypoglycemia and its unfavorable consequences, such as stimulation of cortisol and adrenal androgen secretion, in women with polycystic ovarian syndrome.

Enrollment: 66 patients

Sex: Female

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Females ages 18-45
• Women who are overweight, and have irregular periods or have been diagnosed with Polycystic Ovarian Syndrome

Exclusion criteria

• Use of oral contraceptives
• Impaired glucose tolerance
• Diabetes mellitus, and any other systemic illnesses such as renal, hepatic, gastrointestinal, severe hyperlipidemia and hypertension that require medication
• Schizophrenia
• Having a pacemaker
• Current viral infection
• Smoking alcohol intake (more than 2 drinks/week)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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66 participants in 3 patient groups

1

Active Comparator group

Description:

Subject will follow their usual diet for 4 weeks, at week 6 they will be randomized to receive either flax seed oil, fish oil, or soybean oil capsules for 6 weeks.

Treatment:

Dietary Supplement: Fish Oil

Dietary Supplement: Flax Seed Oil

Dietary Supplement: Soybean Oil

2

Active Comparator group

Description:

Subject will follow their usual diet for 4 weeks, at week 6 they will be randomized to receive either flax seed oil, fish oil, or soybean oil capsules for 6 weeks.

Treatment:

Dietary Supplement: Fish Oil

Dietary Supplement: Flax Seed Oil

Dietary Supplement: Soybean Oil

3

Active Comparator group

Description:

Subject will follow their usual diet for 4 weeks, at week 6 they will be randomized to receive either flax seed oil, fish oil, or soybean oil capsules for 6 weeks.

Treatment:

Dietary Supplement: Fish Oil

Dietary Supplement: Flax Seed Oil

Dietary Supplement: Soybean Oil