Compare Efficacy Nebulized and Intravenous Magnesium Sulphate in Thai Children

Queen Sirikit National Institute of Child Health

Status: Unknown

Conditions: Acute Severe Asthma

Treatments: Drug: isotonic magnesium sulphate; Drug: 50% magnesium sulphate

Study type: Interventional

Funder types: Other

Identifiers

NCT02112305

EC 104/2557

Details and patient eligibility

About

The purpose of this study is to determine whether nebulized magnesium sulphate is effective in the treatment of acute severe asthma when comparison with intravenous magnesium sulphate

Full description

Intervention: At randomization eligible patients were allocated to receive 2.5ml of isotonic magnesium sulphate (150 mg,245 mmol/L) on three occasional at 20 minutes interval or standard treatment 50 mg/kg intravenous magnesium sulphate. The asthma severity score was record at 0,20,40,60,120,180,240 minutes post randomization. Adverse event were assessed at each assessment point. Patients were followed up until discharge from hospital to collect secondary outcome data.

Enrollment: 40 estimated patients

Sex: All

Ages: 2 to 15 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children age 2-15 years presenting with severe asthma or persistent wheeze without responding to conventional therapy

Exclusion criteria

• chronic lung disease
• history of adverse reaction form magnesium sulphate
• life threatening condition

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

40 participants in 2 patient groups

isotonic magnesium sulphate

Experimental group

Description:

2.5 ml of isotonic magnesium sulphate (150 mg, 245 mmol/L) on three occasional at 20 minutes interval

Treatment:

Drug: isotonic magnesium sulphate

50% magnesium sulphate

Active Comparator group

Description:

magnesium sulphate 50mg/kg/dose intravenous drip in 20 minutes for one dose

Treatment:

Drug: 50% magnesium sulphate