Compare the Analgesic Effect of Different Anesthesia and Postoperative Analgesic Methods in Uniportal VATS Lung Surgery (CDAAMIUVLS)

Fudan University

Status and phase: Unknown; Phase 1

Conditions: Postoperative Pain; Single-incision Thoracoscopic Surgery

Treatments: Combination Product: epidural anesthesia; Combination Product: general anesthesia

Study type: Interventional

Funder types: Other

Identifiers

NCT03311737

zs20170511

Details and patient eligibility

About

This is a single center, randomized, single blind study to compare the analgesic effect of different anesthesia and postoperative analgesic methods in uniportal VATS lung surgery.

Full description

Combining epidural with general anesthesia is regarded as the gold standard of general thoracic surgery. The uniportal VATS lung surgery have advantages of minimal invasive surgical incision, less postoperative pain, and so on. Whether general anesthesia can become an alternative method of combining epidural with general anesthesia in uniportal VATS lung surgery, investigators thus plan to make a comparison on intraoperative stress response, postoperative pain, immune function of patients，and hospital expenses.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients elective uniportal VATS lung surgery;
• BMI 18-30 kg/m2.

Exclusion criteria

• Patient refuse;
• ASA≥3;
• Patients allergic to use anesthetics (propofol,rocuronium), patients with liver and/or kidney and/or mental dysfunction.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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100 participants in 2 patient groups

general anesthesia group

Experimental group

Description:

The patients in this group receive general anesthesia preoperatively, and use patient controlled intravenous analgesia postoperatively.

Treatment:

Combination Product: general anesthesia

epidural group

Active Comparator group

Description:

The patients in this group receive general anesthesia combined with epidural anesthesia, and use patient controlled epidural analgesia postoperatively.

Treatment:

Combination Product: epidural anesthesia