Compare the Operating Condition of Two Levels of Muscle Relaxation on Facial Nerve MEP Monitoring in CPA Surgery

Muhammad Magdy Gaber

Status: Completed

Conditions: Cerebellopontine Angle Tumor

Treatments: Drug: Rocroniom, Non Depolarizing Muscle Relaxant

Study type: Interventional

Funder types: Other

Identifiers

NCT04148534

D-4-2019

Details and patient eligibility

About

compare the operating condition of two different levels of muscle relaxation on facial nerve monitoring using transcranial motor evocked potential in CPA surgery .

• To Estimate End to start facial nerve MEP amplitude ratio
• To determine the effect of neuromuscular relaxant degrees on recovery and
• Assessment of propofol doses needed for enhancement of early recovery and ambulation.

Full description

40 Patients aged from 18-60 years old undergoing Cerebellopontine angle surgery. Patients will be one of two groups: Both Induction will be accomplished with fentanyl, propofol , rocronium infusion will be given randomly to one of the groups.

Depth of anaesthesia, neurotransmitter monitoring and facial nerve neurophysiological monitoring will be done.

Enrollment: 40 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients age between >18 and<60.
• Patients scheduled for neurosurgical CPA surgeries
• Ability to sign the consent
• ASA classification I, II

Exclusion criteria

• ASA > II
• Hemodynamically unstable
• Disease affecting neuromuscular transmission (myasthenia gravies ...etc.)
• GCS < 15.
• Any cardiac patient (ischemic heart disease - cardiomyopathy...etc.)

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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40 participants in 2 patient groups, including a placebo group

muscle relaxant

Active Comparator group

Description:

patient who will receive muscle relaxant, patients will receive rocronium infusion by (5 mcg/kg/min) , maintain partial NMB TOF count 2 and targeting BIS = (40-60)

Treatment:

Drug: Rocroniom, Non Depolarizing Muscle Relaxant

without muscle relaxant

Placebo Comparator group

Description:

patient who will not receive muscle relaxant, will recieve normal saline targeting BIS = 40-60.

Treatment:

Drug: Rocroniom, Non Depolarizing Muscle Relaxant