Comparing Cardiovascular Effects of 1:100,000 and 1:200,000 Epinephrine Solutions

Rio de Janeiro State University

Status and phase: Completed; Phase 4

Conditions: Cardiovascular Response to Epinephrine

Treatments: Drug: Epinephrine 1:100,000; Drug: Epinephrine 1:200,000

Study type: Interventional

Funder types: Other

Identifiers

NCT02735018

496.117

Details and patient eligibility

About

The study aim to evaluate systemic response of patients when 2 different concentrations of Epinephrine are injected during inferior alveolar nerve block for wisdom teeth extraction.

Enrollment: 40 patients

Sex: All

Ages: 13 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Class I patients according to the American Society of Anesthesiology (ASA),
• Indication for third molars extraction,
• Similar degree of complexity, according to the classification of Pell and Gregory.

Exclusion criteria

• Patients with systemic conditions,
• Patients with known allergy to any component of the anesthetic solution.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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40 participants in 2 patient groups

Epinephrine 1:100,000

Experimental group

Description:

Inferior alveolar nerve block with Epinephrine 1:100.000

Treatment:

Drug: Epinephrine 1:100,000

Epinephrine 1:200,000

Experimental group

Description:

Inferior alveolar nerve block with Epinephrine 1:200.000

Treatment:

Drug: Epinephrine 1:200,000