Comparing Cognitive Therapy and Exposure Therapy in Individuals With Hypochondriasis

Goethe University

Status and phase: Completed; Phase 3

Conditions: Hypochondriasis; Somatoform Disorders

Treatments: Behavioral: Psychotherapy (CT or ET)

Study type: Interventional

Funder types: Other

Identifiers

NCT01119469

WE 4654/2-1, WE 4654/2-3

Details and patient eligibility

About

This study will compare the efficacy of cognitive therapy and exposure therapy for treating hypochondriasis.

Full description

Hypochondriasis is defined as a preoccupation with the fear of having a serious disease based on the person's misinterpretation of bodily symptoms (APA). For a long time hypochondriasis was seen as difficult to treat. Meanwhile effective psychological treatment for hypochondriasis exists. Psychotherapies using cognitive therapy (CT), cognitive behavioral therapy (CBT), exposure therapy (ET) or behavioral stress management approaches are effective in reducing symptoms of hypochondriasis. However, few studies compare different types of psychotherapy. In addition, in these studies numbers of participants were small, no differences between different treatments were found, and one third of the participants showed no satisfactory change. This study will compare the efficacy of CT and ET in a larger sample of 84 participants.

Participants in this randomized controlled trial (RCT) will first undergo baseline assessment. Then they will be randomly assigned to either CT, ET or a waiting list (WL), all conditions are for the duration of 12 weeks. CT includes psychoeducation, attention training, cognitive restructuring, behavioral experiments, imagery rescripting and relapse prevention. ET includes change of safety behavior, exposition (in sensu and in vivo), and relapse prevention. Both treatment trials contain the identical number of sessions. Treatment response will be assessed at week 12 and additionally one and three years after treatment. Participants of the WL will be assigned to CT or ET after the waiting period.

Enrollment: 84 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meets DSM-IV criteria for hypochondriasis
• German fluency and literacy
• Informed consent

Exclusion criteria

• Major medical illness expected to worsen significantly
• Currently in psychotherapy
• Suicidal tendency
• Clinical diagnosis of alcohol or drug addiction, schizophrenia, schizoaffective disorder or bipolar disorder according to DSM-IV

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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84 participants in 3 patient groups

Cognitive Therapy (CT)

Experimental group

Description:

There will be 12 50-minute individual sessions conducted at weekly intervals. Booster sessions will be conducted one, three and six months after treatment. Sessions include psychoeducation, attention training, cognitive restructuring, behavioral experiments, imagery rescripting and relapse prevention.

Treatment:

Behavioral: Psychotherapy (CT or ET)

Exposure Therapy (ET)

Experimental group

Description:

There will be 12 50-minute individual sessions conducted at weekly intervals. Booster sessions will be conducted one, three and six months after treatment. Sessions include change of safety behavior, exposition (in sensu and in vivo), and response prevention.

Treatment:

Behavioral: Psychotherapy (CT or ET)

Waiting List (WL)

No Intervention group

Description:

12 weeks waiting time