Comparing Different Routes and Doses of Phytonadione (Vitamin K) for Reversing Warfarin Treated Patients With Hip Fracture Before Surgery

HaEmek Medical Center, Israel

Status: Withdrawn

Conditions: Complications; Bleeding

Treatments: Drug: Phytonadione

Study type: Interventional

Funder types: Other

Identifiers

NCT00905229

02-09

Details and patient eligibility

About

It is well known that femoral neck fractures carry a significant increase in patients' mortality and that surgical intervention is the preferred treatment.

Any delay in operating on such patients would inevitably increase their risk of developing complications. One of the reasons for such unintentional delay would be the hypercoagulative status of patients taking warfarin. The CHEST 2008 guidelines suggest reversing warfarin with Vitamin K for patients who need urgent operation. The aim of this study is to compare different roots and doses of Vitamin K.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• hip fracture patients on warfarin

Exclusion criteria

• pregnancy
• vitamin k sensitivity

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

PO (by mouth)

Active Comparator group

Description:

2.5 mg P.O Vitamin K

Treatment:

Drug: Phytonadione

Drug: Phytonadione

IV (intravenous )

Active Comparator group

Description:

0.5 mg IV Vitamin K

Treatment:

Drug: Phytonadione

Drug: Phytonadione