Comparing Diuretic Strategies in Hospitalized Heart Failure

Stanford University

Status and phase: Withdrawn; Phase 4

Conditions: Heart Failure

Treatments: Drug: Loop Diuretics vs. loop + thiazide diuretics

Study type: Interventional

Funder types: Other

Identifiers

NCT03999216

51720

Details and patient eligibility

About

We will conduct a pragmatic randomized trial comparing whether using a combination of two types of diuretics (loop + thiazide) compared with using a single diuretic (loop only) will result in shorter hospital stays for patients hospitalized with heart failure.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Any adult (age ≥18 years) admitted to the Heart Failure Service at Stanford Health Care with an indication for treatment with a diuretic.

Exclusion criteria

1. admission to the intensive care unit or cardiac care units
2. maintenance dialysis on admission
3. any mechanical circulatory support on admission
4. history of heart transplant
5. allergy / intolerance to loop or thiazide diuretics
6. admission serum sodium < 125 meq/L (from EPIC)
7. admission serum potassium < 3.0 meq/L (from EPIC)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

Loop only

Active Comparator group

Description:

Participants will receive a loop diuretic for up to the first 72 hours of hospitalization. The specific drug, dose and route are left to the treating providers.

Treatment:

Drug: Loop Diuretics vs. loop + thiazide diuretics

Loop + Thiazide

Active Comparator group

Description:

Participants will receive a loop+thiazide diuretic for up to the first 72 hours of hospitalization. The specific drugs, doses and routes are left to the treating providers.

Treatment:

Drug: Loop Diuretics vs. loop + thiazide diuretics