Comparing Effectiveness of Merocel and Packing With Tranexamic Acid in the Management of Anterior Epistaxis

Kecioren Education and Training Hospital

Status and phase: Completed; Phase 4

Conditions: Epistaxis; Tranexamic Acid; Nasal Packing

Treatments: Device: Merocel; Drug: Normal saline; Drug: Tranexamic Acid

Study type: Interventional

Funder types: Other

Identifiers

NCT03360045

71146310-511.06-E.223856

Details and patient eligibility

About

Aim of this study is evaluate whether superior nasal compression with tranexamic acid to simple nasal compression and Merocel packing.

In this study, patients who presented with non-traumatic anterior epistaxis to emergency departments will be included in this study. Three different therapy option are created; first, nasal compression with tranexamic acid, second, simple nasal compression without any drugs. And third, packing with Merocel.

Enrollment: 135 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with anterior epistaxis older than 18 year and accept to participate in the study

Exclusion criteria

• Patients younger than 18 years
• Patients who used anticoagulation therapy
• Patients who have hemodynamically instability
• Traumatic epistaxis
• Patients who have known bleeding disorder

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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135 participants in 3 patient groups, including a placebo group

Tranexamic acid group

Active Comparator group

Description:

500mg tranexamic acid is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually.

Treatment:

Drug: Tranexamic Acid

Placebo group

Placebo Comparator group

Description:

5ml normal saline is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually.

Treatment:

Drug: Normal saline

Merocel Group

Active Comparator group

Description:

Merocel packing is applied.

Treatment:

Device: Merocel