Comparing Efficacy of 14-day Therapy Doxycycline With Bismuth Subsalicylate Versus Levofloxacin With Tinadizole on Treatment Helicobacter Pylori

Damascus Hospital

Status and phase

Completed

Phase 4

Conditions

Helicobacter Pylori Infection

Treatments

Drug: Levofloxacin 500mg

Drug: Doxycycline

Study type

Interventional

Funder types

Other

Identifiers

NCT04348786

G1-19

Details and patient eligibility

About

Comparison Efficacy of 10-days Therapy with Doxycycline with Bismuth Subsalicylate Versus Levofloxacine with Tinadizole on Eradication of Helicobacter Pylori in Syrian population.

Enrollment

78 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients are aged greater than 18 years old who have H. pylori infection diagnosed by any of following three methods:
Positive rapid urease test (CLOtest).
Histologic evidence of H. pylori by modified Giemsa staining.
Positive 13C-urea breath test. without prior eradication therapy and are willing to receive therapy.

Exclusion criteria

Children and teenagers aged less than 18 years.
Previous eradication treatment for H. pylori.
Patients who took any drug, which could influence the study results such as proton pump inhibitor, H2 blocker, mucosal protective agent and antibiotics.
History of gastrectomy.
Gastric malignancy, including adenocarcinoma and lymphoma,
Previous allergic reaction to antibiotics (Amoxicillin, Tinadizole,
Doxycycline,Bismuth subsalicylate,) and prompt pump inhibitors (Es- omeprazole).
Contraindication to treatment drugs.
Pregnant or lactating women.
Severe concurrent disease.
Liver cirrhosis.