Comparing Efficacy of Azithromycin and Probiotics for Treatment of Acne Vulgaris

Pak Emirates Military Hospital

Status and phase: Completed; Phase 3

Conditions: Acne Vulgaris

Treatments: Drug: Azithromycin; Drug: Benzoyl Peroxide 4 % Topical Cream; Drug: Probiotic Formula

Study type: Interventional

Funder types: Other

Identifiers

NCT05629468

A/28/EC/337/2021

Details and patient eligibility

About

the goal of this clinical trial is to measure the efficacy of probiotics for treatment of acne vulgaris, to compare it with azithromycin and to measure the synergistic effect of azithromycin and probiotics for treatment of acne vulgaris

Full description

this study aims to answer this research question: in patients of acne vulgaris, is use of probiotics as efficacious as azithromycin in treating acne lesions & improving quality of life? total 75 patients were divided into 3 groups. group A received azithromycin, group B received probiotics and group C received both drugs. a topical cream was also advised to all groups. outcome was measured as reduction in total lesion count and improvement in patients' quality of life via reduction in Dermatology Life Quality Index score.

Enrollment: 75 patients

Sex: All

Ages: 15 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed Patients of Mild and Moderate acne
• Aged between 15 and 35 years

Exclusion criteria

• Severe acne or any systemic inflammatory disease
• Other oral treatment for acne
• Allergic to any drug being used in the study
• Pregnancy
• PCOs
• Any drug which can interact with azithromycin

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

75 participants in 3 patient groups

Azithromycin and Topical

Active Comparator group

Description:

group A (n=25) received tab. azithromycin 250mg oral on alternate days and topical cream benzoyl peroxide 4% twice a day daily for a period of 3 months

Treatment:

Drug: Benzoyl Peroxide 4 % Topical Cream

Drug: Azithromycin

Probiotics and Topical

Experimental group

Description:

group B (n=25) received Probiotic sachet oral once a day everyday and topical cream benzoyl peroxide 4% twice a day daily for a period of 3 months

Treatment:

Drug: Probiotic Formula

Drug: Benzoyl Peroxide 4 % Topical Cream

Azithromycin and Probiotics and Topical

Other group

Description:

combination group C (n=25) received tab. azithromycin 250mg oral on alternate days, Probiotic sachet oral once a day everyday and topical cream benzoyl peroxide 4% twice a day daily for a period of 3 months

Treatment:

Drug: Probiotic Formula

Drug: Benzoyl Peroxide 4 % Topical Cream

Drug: Azithromycin