Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy (POTO)

Seoul National University

Status

Unknown

Conditions

Thyroid Nodule

Surgical Wound Infection

Treatments

Drug: Amoxicillin Clavulanate

Study type

Interventional

Funder types

Other

Identifiers

NCT03295955

1708-028-875

Details and patient eligibility

About

Transoral endoscopic thyroid surgery is a emerging surgical technique for thyroid surgery. This study to investigate the need for postoperative antibiotics in transoral endoscopic thyroid surgery.

Full description

To prevent possible infection from the oral cavity flora, most surgeons prescribe postoperative oral antibiotics more than 3 to 7 days after surgery. Currently, there's no clinical evidence that postoperative oral antibiotics is necessary or not in transoral endoscopic thyroid surgery. The investigator will conduct randomization after transoral thyroid surgery with two groups : postoperative oral antibiotics group versus no oral antibiotics group.

Enrollment

50 estimated patients

Sex

All

Ages

20 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients who planned to Transoral endoscopic thyroidectomy
Age between 20 to 70
Voluntarily consenting to the study and study agreement
No local invasion or distant metastasis
Normal vocal cord function in laryngoscopic exam
No significant abnormalities in preoperative laboratory tests

Exclusion criteria

Take aspirin or antiplatelet drugs within 7 days before admission
Uncontrolled hypertension, diabetes, chronic renal failure, or coagulation disease
History of cardiovascular disease (angina pectoris, heart failure, myocardial infarction, history of coronary artery disease, stroke, transient ischemic attack)
Substance abuse and alcohol abuse
History of esophageal and airway diseases
Patient was participated in other clinical trials within 30 days
History of neck irradiation or surgery
History of drug allergies
Pregnant or lactating women