Comparing Exercise Programs for Managing Knee Osteoarthritis

Bursa Uludag University

Status: Completed

Conditions: Osteoarthritis; Knee OA; Osteoarthritis (OA) of the Knee

Treatments: Behavioral: Home-Based Exercise; Device: Whole-body Vibration (WBV) Training; Behavioral: Progressive Resistance Exercise (PRE)

Study type: Interventional

Funder types: Other

Identifiers

NCT06711341

2023-15/19

Details and patient eligibility

About

The goal of this clinical trial is to assess and compare the effectiveness of three different exercise modalities-whole-body vibration exercise, progressive resistance exercise, and home-based exercise -in improving quadriceps isometric muscle strength, physical function, balance, knee pain, osteoarthritis symptoms, and overall quality of life in individuals with knee osteoarthritis.

The main questions it aims to answer are:

• How do WBV, PRE, and home-based exercise compare in improving quadriceps strength in people with knee osteoarthritis?
• Which exercise modality leads to the greatest improvements in physical function, balance, knee pain, and quality of life?

Researchers will compare the three exercise regimens to determine which is most effective for improving knee function and relieving osteoarthritis symptoms.

Participants will:

• Engage in whole-body vibration exercise, progressive resistance exercise, or home-based exercise for 3 weeks.
• Undergo assessments before and at the end of the exercise program, including tests for physical function and balance (Timed Up and Go Test, 5x Sit to Stand Test) and questionnaires to evaluate knee osteoarthritis symptoms (WOMAC), quality of life (SF-36), and self-reported knee pain (Numeric Rating Scale).

Enrollment: 69 patients

Sex: All

Ages: 45 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. participants between the ages of 45-70,
2. diagnosed with knee osteoarthritis according to ACR criteria (unilateral or bilateral),
3. having grade 2 or 3 tibiofemoral knee osteoarthritis according to Kellgren-Lawrence staging,
4. having knee pain due to OA for a minimum of 3 months prior to enrollment,
5. patients whose medical treatment is not expected to change during the study period.

Exclusion criteria

1. having or had undergone knee surgery,
2. patients unable to walk without support,
3. having musculoskeletal limitations that prevent participation in resistance exercises (contracture, fracture, etc.),
4. other neurological, cardiac, respiratory and systemic diseases that will affect physical activity,
5. currently implementing a regular exercise or physical therapy program specific to knee OA

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

69 participants in 3 patient groups

Whole-body Vibration (WBV) Training Group

Active Comparator group

Description:

Participants undergo WBV training as outlined in the WBV intervention, 3 days per week for 3 weeks. The sessions begin with a duration of 10 minutes in the first week, with the duration increasing each week thereafter. They also perform the home exercises assigned to the Control group on the same days as their PRE sessions.

Treatment:

Device: Whole-body Vibration (WBV) Training

Progressive Resistance Exercise (PRE) Group

Active Comparator group

Description:

Participants undergo PRE training as outlined in the PRE intervention, 3 days per week for 3 weeks. The training focuses on strengthening the quadriceps muscles using ankle weights. The load is determined using the DeLorme principle at the start of each week. They also perform the home exercises assigned to the Control group on the same days as their PRE sessions.

Treatment:

Behavioral: Progressive Resistance Exercise (PRE)

Control Group (Home-Based Exercise)

Active Comparator group

Description:

Participants perform home exercises three days per week for 3 weeks. The exercises consist of range of motion (ROM) and isometric strengthening exercises as detailed in the intervention section.

Treatment:

Behavioral: Home-Based Exercise