Comparing Intra-articular Betamethasone (Diprospan) and Triamcinolone Acetonide Injection in Knee Osteoarthritis

Thammasat University

Status and phase: Completed; Phase 4

Conditions: Knee Osteoarthritis

Treatments: Drug: Betamethasone Dipropionate / Betamethasone Sodium Phosphate; Drug: Triamcinolone Acetonide 40mg/mL

Study type: Interventional

Funder types: Other

Identifiers

NCT05139875

MTU-EC-OT-1-266/64

Details and patient eligibility

About

The purpose of this study is to compare the efficacy of Intra-articular corticosteroid injection between Betamethasone (Diprospan) and Triamcinolone acetonide for treatment of knee osteoarthritis

Full description

After being informed about the study and potential risks, all patients giving written informed consent will be chosen for eligibility for the study entry. At day 0 (before intra-articular injection), patients who meet the eligibility criteria will be randomized in a double-blind manner (participant and investigator) in a 1:1 ratio to Betamethasone (Diprospan 1 ml) or Triamcinolone acetonide (40 mg) single intra-articular injection

Enrollment: 105 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Symptomatic Primary knee osteoarthritis (Kellgren-Lawrence stage 2 or 3)
2. Failed other conservative treatment
3. Comply with protocol

Exclusion criteria

1. Allergy to any of the medications in this protocol (Betamethasone, Triamcinolone, Paracetamol, Tramadol)
2. Previous fracture or surgical procedure
3. Previous intra-articular injection in the past 6 months
4. Previous oral Symptomatic slow-acting drugs for osteoarthritis (SYSADOA) (Glucosamine, Diacerein) used in the past 6 months
5. Current infection in the affected limb
6. Uncontrolled Diabetes Mellitus
7. Primary or secondary adrenal insufficiency
8. Coagulopathy or current anticoagulant used
9. Current steroid used
10. Lower extremity weakness

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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105 participants in 2 patient groups

Betamethasone (Diprospan)

Experimental group

Description:

Participant received single intra-articular Betamethasone Dipropionate / Betamethasone Sodium Phosphate 1 ml

Treatment:

Drug: Betamethasone Dipropionate / Betamethasone Sodium Phosphate

Triamcinolone acetonide

Active Comparator group

Description:

Participant received single intra-articular Triamcinolone acetonide 40 mg

Treatment:

Drug: Triamcinolone Acetonide 40mg/mL