Comparing Intubating Conditions Using Succinylcholine or Rocuronium for Rigid Bronchoscopy

Helio's Health

Status: Suspended

Conditions: Intubating Conditions; Patient Satisfaction; Postoperative Myalgia

Treatments: Drug: Rocuronium 0,6; Drug: Succinylcholine; Drug: Rocuronium 0,3

Study type: Interventional

Funder types: Industry

Identifiers

NCT01996358

HSK004

Details and patient eligibility

About

Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application aof rocuronium, reversed by sugammadex. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM) as well as patient satisfaction for these two muscle relaxants.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• age > 18 yr
• scheduled for elective rigid bronchoscopy

Exclusion criteria

• known neuromuscular disease
• significant hepatic or renal dysfunction
• family history of malignant hyperthermia
• known allergy to one of the drugs used in this protocol
• pregnancy or breastfeeding

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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150 participants in 3 patient groups

Succinylcholine

Active Comparator group

Description:

Succinylcholine 0,5mg/kg as muscle relaxant during induction of anaesthesia for rigid bronchoscopy

Treatment:

Drug: Succinylcholine

Rocuronium 0,3

Active Comparator group

Description:

Rocuronium 0,3 mg/kg during induction of anaesthesia for rigid bronchoscopy. At the end of procedure 2mg/kg sugammadex for reversal of neuromuscular block are applied.

Treatment:

Drug: Rocuronium 0,3

Rocuronium 0,6

Active Comparator group

Description:

Rocuronium 0,6 mg/kg during induction of anaesthesia for rigid bronchoscopy. At the end of procedure 2mg/kg sugammadex for reversal of neuromuscular block are applied.

Treatment:

Drug: Rocuronium 0,6