Comparing Metabolic Characteristics of Persistent Critically Ill Non-COVID and COVID-19 Patients (MetaCO-nonCO)

Vaud University Hospital Center

Status: Completed

Conditions: Persistent Critical Illness

Treatments: Other: Nutrition therapy according to ICU protocol

Study type: Observational

Funder types: Other

Identifiers

NCT05026151

CER2020-01453

Details and patient eligibility

About

The Corona Virus Disease-19 (COVID-19) pandemic has resulted in an overwhelming number of intensive care (ICU) patient admissions, generally for acute respiratory distress, often resulting in persistent critical illness (PCI). Little is known about their metabolic and nutritional characteristics compared to other non-COVID (non-CO) categories of patients.

The aim is to compare the metabolic characteristics and gastro-intestinal function of the previously admitted non-CO and COVID persistent critically ill patients, and the adherence to the ICU nutrition protocol.

Prospective observation study including two consecutive cohorts of PCI, defined by a prolonged mechanical ventilation requirement longer than 10days.

Full description

The metabolic and nutritional characteristics of the COVID-19 patients requiring prolonged ICU treatment compared to other non-COVID (non-CO) categories of patients remain poorly described. The aim was to compare the metabolic characteristics of the previously admitted non-CO and COVID PCI patients.

Prospective observation study including two consecutive cohorts of PCI, defined as requiring a mechanical ventilation for >10 days.

The comparative cohort is the first patient cohort previously registered as NCT03938961.

Variables: demographic data, severity score (SAPS2, organ failure (SOFA) scores), Nutrition Risk Screening (NRS) score, C-reactive protein (CRP), blood phosphate. Nutritional variables: energy intake (detail of protein, lipids, glucose), fasting time, feeding route, prealbumin values, bowel activity, insulin requirements Outcome: length of mechanical ventilation, ICU and hospital stay and outcome. Descriptive statistics

Enrollment: 110 patients

Sex: All

Ages: 18 to 95 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients requiring more than 10 days on mechanical ventilation

Exclusion criteria

• patients refusing use of their coded data
• admission for brain injury or after cardiac arrest
• admission for major burns >20% body surface area (BSA)

Trial design

110 participants in 2 patient groups

non-CO

Description:

Consecutive persistent critically ill patients requiring more than 10 days of mechanical ventilation, admitted just before the first COVID-19 wave

Treatment:

Other: Nutrition therapy according to ICU protocol

COVID

Description:

Consecutive persistent critically ill COVID-19 patients requiring more than 10 days of mechanical ventilation, admitted during the first COVID-19 wave

Treatment:

Other: Nutrition therapy according to ICU protocol