Comparing Microneedling and Injectable Platelet Rich Fibrin to Hyaluronic Acid In Papilla Reconstruction ((PRF) (HA))

King Abdulaziz University

Status and phase: Active, not recruiting; Early Phase 1

Conditions: Papilla Reconstruction

Treatments: Biological: Injectable Platelet Rich Fibrin; Other: Hyaluronic Acid (HA)

Study type: Interventional

Funder types: Other

Identifiers

NCT07280507

117-10-24 (Registry Identifier)

King AbdulAziz University (Other Identifier)

Details and patient eligibility

About

This randomized split-mouth clinical trial aims to compare the clinical effectiveness of microneedling combined with injectable platelet-rich fibrin (i-PRF) versus hyaluronic acid (HA) gel injection in the reconstruction of Class I interdental papilla loss. The study hypothesizes that MN + i-PRF will yield greater papillary regeneration, offering a minimally invasive, biologically active alternative to traditional surgical approaches for soft-tissue esthetic rehabilitation.

Enrollment: 7 estimated patients

Sex: All

Ages: 18 to 45 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Plaque index <1
• Gingival index <1
• Class I papillary loss (Nordland and Tarnow classification)
• Probing depth ≤4 mm at the test site
• Inter-proximal bone crest distance ≤7 mm from the contact point.

Exclusion criteria

• Pregnancy
• Lactation
• Uncontrolled systemic diseases (e.g., diabetes)
• Anticoagulant therapy
• Recent radiotherapy
• Orthodontic treatment
• Midline diastema
• High frenum attachment
• Class II/III papillary loss.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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7 participants in 2 patient groups

HA

Experimental group

Description:

Hyaluronic Acid Filler

Treatment:

Other: Hyaluronic Acid (HA)

iPRF

Active Comparator group

Treatment:

Biological: Injectable Platelet Rich Fibrin