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Comparing NAVA Levels in Intubated and Recently Extubated Neonates to Determine Optimal Non-invasive Ventilatory Support

P

ProMedica Health System

Status

Completed

Conditions

Other Specified Respiratory Problems in Fetus or Neonate

Treatments

Other: NAVA level

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

Neurally adjusted ventilatory assist (NAVA) is a mode of mechanical ventilation that uses the diaphragm's normal electrical activity to deliver a mechanically supported breath. The amount of support provided is determined in part by the NAVA level, where a higher NAVA level will provide higher level of support and unload more of the work of the diaphragm. The purpose of this study is to compare the optimal NAVA level in neonates while on mechanical ventilation while intubated and after being extubated.

Full description

Baseline measurements will be taken. The NAVA titration study will then be done. The NAVA level will be set at a starting value of 0.1 cm H2O/mcV and systematically increased by 0.5 cm H2O/mcV every three minutes to a maximum of 3 cmH2O/mcV. Once the NAVA titration study has been completed, the patient will be extubated. There will be a stabilization period following extubation (15-30 minutes), and then the NAVA titration study will be repeated.

Enrollment

15 patients

Sex

All

Ages

23 to 40 weeks old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Neonates on NAVA ventilation

Exclusion criteria

Trial design

Primary purpose

Diagnostic

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

15 participants in 1 patient group

Intubated
Experimental group
Description:
NAVA level from 0.1 to 3
Treatment:
Other: NAVA level
Other: NAVA level

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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