Comparing Nitrous Oxide and Carbon Dioxide for Laparoscopic Cholecystectomy

Ahvaz Jundishapur University of Medical Sciences

Status

Completed

Conditions

Pneumoperitoneum

Treatments

Procedure: nitrous oxide use for pneumoperitoneum creation

Study type

Interventional

Funder types

Other

Identifiers

NCT01512511

u-89140

Details and patient eligibility

About

There is no general agreement about the ideal gas for pneumoperitoneum. CO2, now in common use, has not compared to N2O sufficiently to disclose which one has minimal "physiological" invasiveness characters. Assigned randomly to carbon dioxide or nitrous oxide group, the hemodynamic and respiratory parameters (heart rate, mean arterial blood pressure, end-tidal CO2, minute ventilation, and O2 saturation) before pneumoperitoneum and during it were recorded. Pain, as perceived by patients, is measured 2, 4 and 24 hours after the procedure by visual analogue scale. Vomiting and use of analgesics and antiemetics were recorded and compared.

Enrollment

64 patients

Sex

All

Ages

Under 65 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

developed gallstones
candidates for laparoscopic cholecystectomy
written informed consent
ASA Score = 1&2

Exclusion criteria

signs and complications of gallstones in admission include acute cholecystitis and suppurative cholangitis
complete Inability to move
severe physical or mental disorders leading to inability to communicate -Pregnancy and
cancer