Comparing Opioids Vs NSAIDs for Postoperative Pain Management in Unilateral Primary Open Inguinal Hernia Repair

Pakistan Air Force (PAF) Hospital Islamabad

Status: Completed

Conditions: Pain Management; Inguinal Hernia Unilateral

Treatments: Drug: Pain management after surgery

Study type: Interventional

Funder types: Other

Identifiers

NCT06608056

SGR-2021-137-2499-2 (Other Identifier)

Details and patient eligibility

About

To control post-operative pain, multiple drugs are available, and in the western countries opioids are preferred. However, they have their own side effects, and so to reduce their dependence, multiple adjuncts are used. We compared the use of opioids vs just non steroidal anti-inflammatory drugs on post-operative pain control following inguinal hernia surgery

Full description

Inguinal hernia repair is one of the most common surgeries performed by general surgeons worldwide. The preferred procedure for primary open inguinal hernias is open mesh repair (tension-free)-also called Lichtenstein repair. Opioids remain the mainstay for post-operative analgesia, however, they have a tendency for dependence along with other side effects. Non-steroidal anti-inflammatory drugs (NSIADs) have been used as adjuncts to decrease the use of opioids, however, usually NSAIDs are not used in isolation following surgery. We compared post-operative analgesia following primary open inguinal hernia repair, with patients receiving only opioids vs patients only receiving NSAIDs. 60 patients were randomized in to 2 groups. Group A patients received tramadol injection (opioid) every 8 hours, while patients in Group B received injection ketorolac (NSAID) every 8 hourly. Pain was measured using visual analogue score at 2-, 6-, 12- and 24-hours following surgery.

Enrollment: 60 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Undergoing elective primary unilateral open inguinal hernia repair under spinal anesthesia - Lichtenstein repair with prolene mesh
• ASA I or II
• Ages 18 - 65

Exclusion criteria

• Patient on chronic pain meds
• Patient receiving analgesics 24hrs prior to surgery
• Incarcerated or strangulated hernia or recurrent hernia
• BMI >40
• Allergic to medications being tested in this study

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Tramadol

Experimental group

Description:

Patients received injection tramadol 50 mg intravenously every 8 hourly following surgery

Treatment:

Drug: Pain management after surgery

Ketorolac

Experimental group

Description:

Patients received injection tramadol 30 mg intravenously every 8 hourly following surgery

Treatment:

Drug: Pain management after surgery