Comparing Platelet-Rich Plasma (PRP) Centrifugation Methods on Thrombocyte Concentration and Clinical Improvement of Androgenetic Alopecia

University of Indonesia (UI)

Status: Enrolling

Conditions: Alopecia, Androgenetic

Treatments: Procedure: Platelet-Rich Plasma Injections (PRP) on the Scalp

Study type: Interventional

Funder types: Other

Identifiers

NCT05681897

876/UN2.F1/ETIK/PPM.00.02/2

Details and patient eligibility

About

This research is a preliminary, randomized, double blind clinical trial, which will examine the differences in PRP preparation methods, a single-spin centrifugation of 3000 rpm in 15 minutes compared to a double-spin centrifugation of 1500 rpm in 6 minutes followed by 2500 rpm in 15 minutes, on the results of Thrombocyte Concentration and Clinical Improvement of Androgenetic Alopecia.

Full description

Several examinations will be performed in every visit, including history taking, physical examination, trichoscopy and trichoscan. Laboratory evaluations (complete blood count) for the measurement of the thrombocyte for baseline and PRP will be performed for all assented subjects on the first visit. Each subject will be instructed to apply 5% topical minoxidil twice a day everyday as primary therapy during the study

Enrollment: 30 estimated patients

Sex: Male

Ages: 25 to 59 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Met the criteria of androgenic alopecia (Hamilton Norwood grade III-IV)
• Men between ages 25-59 years old
• Have stopped taking topical anti-androgen or minoxidil for at least one month, or oral anti-androgen or minoxidil for at least three months

Exclusion criteria

• alopecia of any other type
• subject with a history of keloid or blood coagulation disorders underwent anticoagulant therapy
• subjects on Non-Steroidal Anti-Inflammatory Drugs (NSAID) medications in seven days prior to the study
• subjects who had hair treatment using growth factors, including PRP and microneedling within at least six months prior to the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

30 participants in 2 patient groups

Single Spin Group

Other group

Description:

Currently, the standard operating procedures for PRP preparation in dr. Cipto Mangunkusumo National General Hospital is by performing a single-spin centrifugation at 3000 rpm for 15 minutes. This first group will received PRP treatment by single-spin centrifugation at 3000 rpm in 15 minutes in addition to topical minoxidil (5%)

Treatment:

Procedure: Platelet-Rich Plasma Injections (PRP) on the Scalp

Double Spin Group

Active Comparator group

Description:

This group will received double-spin centrifugation PRP treatment at 1500 rpm in 6 minutes and continued at 2500 rpm in 15 minutes in addition to topical minoxidil (5%)

Treatment:

Procedure: Platelet-Rich Plasma Injections (PRP) on the Scalp