Comparing Relative Strengths of Statistical Associations Between Psychological Traits and Vaccination-Related Outcomes I

University of Iowa

Status: Completed

Conditions: Vaccination Hesitancy; Vaccination; Psychological Aspects; Vaccination Promotion

Treatments: Other: Vaccine-Specific Psych Trait Measures; Diagnostic Test: General Psych Trait Measure

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT07172074

5K01AG065440 (U.S. NIH Grant/Contract)

202211127

Details and patient eligibility

About

The goal of this study was to identify psychological motives that had the strongest statistical associations with vaccine outcomes in order to identify novel intervention targets to be used in vaccine promotion efforts. A national sample of US adults completed an online survey containing a variety of vaccine-related measures and psychological trait measures.

Full description

A national sample of US adults were recruited through Dynata, an online survey panel company, to complete an online survey. Participants completed a variety of vaccine-related survey items and an unprecedented number (>20) of psychological trait measures. This was possible by using a Planned Missingness Design, where respondents only answer a predetermined subset of survey questions, which allows us to include more measures without significantly increasing the burden for participants.

Participants were randomized to one of the three question blocks, where each block had a predetermined set of items that were roughly 1/3 of the items from each psychological trait measure. They were also randomized to complete questions that were about the psychological traits in general or about vaccines specifically.

Enrollment: 1,786 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Consent to participate
• Agree to provide quality responses

Exclusion criteria

• Quota completed (Equal #s of respondents in each group)

  • Age group: 18-49, 50-64, 65+
  • Race/ethnicity: Non-Hispanic White, Non-Hispanic Black, Hispanic
  • Income: <$50K, $50K or more
  • Gender: Female, Male or other gender identity

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Factorial Assignment

Masking: Double Blind

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1,786 participants in 3 patient groups

Planned Missingness Design Block A

Experimental group

Description:

Respondents were randomized to complete one of three blocks (items predetermined by being randomized to blocks, with 1/3 of items in each block) of the psychological trait measures

Treatment:

Other: Vaccine-Specific Psych Trait Measures

Diagnostic Test: General Psych Trait Measure

Planned Missingness Design Block B

Experimental group

Description:

Respondents were randomized to complete one of three blocks (items predetermined by being randomized to blocks, with 1/3 of items in each block) of the psychological trait measures

Treatment:

Other: Vaccine-Specific Psych Trait Measures

Diagnostic Test: General Psych Trait Measure

Planned Missingness Design Block C

Experimental group

Description:

Respondents were randomized to complete one of three blocks (items predetermined by being randomized to blocks, with 1/3 of items in each block) of the psychological trait measures

Treatment:

Other: Vaccine-Specific Psych Trait Measures

Diagnostic Test: General Psych Trait Measure