Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty

Nova Scotia Health Authority (NSHA)

Status and phase: Begins enrollment in 1 month; Phase 4

Conditions: Recovery Period; Anesthesia

Treatments: Drug: Chloroprocaine Injection; Drug: Mepivacaine Injection

Study type: Interventional

Funder types: Other

Identifiers

NCT07239999

DGH2025

Details and patient eligibility

About

This study or clinical trial looking to compare 2 types of freezing medications injected into the spinal fluid at the lower back between the vertebrae in patients going to have total knee replacement surgery to check for early legs movement, early discharge from recovery room, walking and hospital discharge. This could save hospital cost of such procedures.

Enrollment: 170 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-III
• Elective outpatient TKA
• BMI less than 40
• Ability to provide surgical consent

Exclusion criteria

• Patient refusal
• Opioid tolerant
• Any contraindications to spinal anesthesia
• Chronic opioid use 3months or more

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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170 participants in 2 patient groups

One arm receives spinal Mepivacaine 50 mg

Active Comparator group

Description:

One arm receives spinal Mepivacaine 50mg for total knee arthroplasty with adductor canal block

Treatment:

Drug: Mepivacaine Injection

Spinal Chloroprocaine group

Active Comparator group

Treatment:

Drug: Chloroprocaine Injection