Comparing the Acute Effects of Different Exercise Approaches in Patients With Multiple Sclerosis

Acibadem University

Status: Completed

Conditions: Multiple Sclerosis

Treatments: Other: Conventional Exercise; Other: Traditional Aerobic Exercise; Other: VR Based Aerobic Exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT06721416

2023-07/229

Details and patient eligibility

About

Multiple Sclerosis (MS) is the second most common neurological disorder in young adults after trauma. Treatments developed today can slow progression and reduce symptoms. Exercise therapy is a useful rehabilitation practice in MS to manage symptoms, restore function, optimize quality of life, ensure well-being and increase participation in daily life activities. In this study, it is planned to investigate the acute effects of conservative and virtual reality (VR)-based aerobic exercise applications and standard exercises that frequently form the rehabilitation programs of individuals with MS in clinics. For this purpose, patients with MS who met the inclusion criteria were given two-week intervals; Conservative aerobic exercise, virtual reality-based aerobic exercise and standard exercise practices will be performed. With the data obtained from this study, it is aimed to investigate the safety of aerobic exercises performed using VR tools that can be used in telerehabilitation applications, which are thought to have a very important place in MS rehabilitation in the future, in terms of acute body temperature increase, cognitive and physical fatigue caused by conservative methods and fNIRS cortical effects of VR-based aerobic exercise applications. It will be possible to prove it with objective methods such as.

Enrollment: 12 patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosed as Relapsing Remitting MS by neurologist according to the McDonald Criteria.
• 18-55 years old.
• EDSS score < 4.5
• Mini mental examination test score ≥ 24
• No MS attack in the last 6 months.
• No visual or vestibular deficits.
• Signed the written consent form.

Exclusion criteria

• Having previous full immersive VR experience.
• Having an additional neurological disease.
• Spasticity in any muscle of the upper extremity > 3, according to MAS.
• Continuing the active physical therapy and rehabilitation program.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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12 participants in 3 patient groups

Virtual Reality Beased

Experimental group

Description:

VR based aerobic exercise

Treatment:

Other: VR Based Aerobic Exercise

Traditional

Experimental group

Description:

Cycling ergometer based aerobic exercise

Treatment:

Other: Traditional Aerobic Exercise

Conventional

Experimental group

Description:

Conventional physical therapy approaches

Treatment:

Other: Conventional Exercise