Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients.

Pakistan Institute of Medical Sciences

Status: Enrolling

Conditions: Fluoride Varnishes; Nanoparticles; Dental Plaque Accumulation

Treatments: Procedure: Fluoride varnish; Procedure: Novel titania nanoparticle infused fluoride varnish

Study type: Interventional

Funder types: Other

Identifiers

NCT07180849

SOD/ERB/2025/91

Details and patient eligibility

About

In this study the investigators aimed to explore the antibiofilm effect of fluoride varnish loaded with titania nanoparticles synthesized from moringa oleifera leaves extract vs conventional fluoride varnish in multibracket fixed orthodontic patients.

Enrollment: 20 estimated patients

Sex: All

Ages: 16 to 30 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients planned for fixed orthodontic treatment.
• Patients within age group 16-30 years.
• Patient with no history of previous orthodontic treatment.
• Patients with no active periodontal diseases.

Exclusion criteria

• Patient undergoing any antibiotic therapy.
• Patients with any craniofacial abnormality.
• Patient with mixed dentition

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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20 participants in 2 patient groups

Group A

Experimental group

Description:

Group A will receive topical application of conventional fluoride varnish.

Treatment:

Procedure: Fluoride varnish

Group B

Experimental group

Description:

Group B will receive topical application of titania nanoparticle infused varnish.

Treatment:

Procedure: Novel titania nanoparticle infused fluoride varnish