Comparing the Effects of Exercise on the Structure and Function of Fat Tissue (CAT)

University of Michigan

Status: Completed

Conditions: Adiposity

Treatments: Diagnostic Test: Oral Glucose Tolerance Test

Study type: Interventional

Funder types: Other

Identifiers

NCT05328570

HUM00179332

Details and patient eligibility

About

Assess differences in structure and biological function of abdominal subcutaneous adipose tissue samples collected from adults who exercise regularly vs. a well-matched cohort of non-exercisers.

Enrollment: 45 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age: 18-40 years old
• Body Mass Index: 23-35 kg/m2
• Women must have regularly occurring menses and must be premenopausal

Exclusion criteria

• Evidence/history of cardiovascular or metabolic disease
• Medications known to affect lipid or glucose metabolism, or inflammation
• Weight instability ≥ ± 6 pounds in the last 6 months
• Tobacco or e-cigarette users
• Women must not be pregnant or actively lactating
• Blood pressure > 140/90 mmHg

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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45 participants in 1 patient group

Oral Glucose Tolerance Test

Experimental group

Description:

Subjects will complete an Oral Glucose Tolerance Test in which glucose is given and blood samples are taken every 15 minutes over a 2 hour period to determine how quickly the glucose is cleared from the blood.

Treatment:

Diagnostic Test: Oral Glucose Tolerance Test