Comparing the Effects of Two Beta Blockers,Metoprolol and Nebivolol,on Ambulatory Blood Pressure and Basal Metabolic Rate

University of Mississippi

Status: Terminated

Conditions: Hypertension

Treatments: Drug: Metoprolol; Drug: Nebivolol

Study type: Interventional

Funder types: Other

Identifiers

NCT00849810

2009-0002

Details and patient eligibility

About

The purpose of the study is to compare the effects of nebivolol and metoprolol on 24-hour ambulatory blood pressure characteristics and basal metabolic rates in patients with hypertension.

Enrollment: 1 patient

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years old or older
• currently be treated at a University of MS Medical Center Internal Medicine Clinics
• currently taking metoprolol succinate for hypertension
• have their hypertension controlled (<140/90).

Exclusion criteria

• uncontrolled hypertension
• severe renal or moderate hepatic impairment
• currently taking CYP 2D6 inducers/inhibitors
• recent stroke (less than 6 months)
• recent myocardial infarction (less than 6 months)
• congestive heart failure
• diagnosed obstructive sleep apnea
• atrial fibrillation
• arm circumference >50 cm

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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1 participants in 1 patient group

Metoprolol to nebivolol

Experimental group

Description:

metoprolol 25-200mg at a stable daily dose for 4 weeks, then change to nebivolol at a comparable stable dose (5-20 mg) for 4 -5 weeks.

Treatment:

Drug: Metoprolol

Drug: Nebivolol