Comparing the Ketogenic Effect of Coconut Oil and Different MCTs (MCT-Coco)

U

Université de Sherbrooke

Status

Completed

Conditions

Healthy Adults

Treatments

Dietary Supplement: Control
Dietary Supplement: Coconut oil + tricaprylin
Dietary Supplement: Coconut oil
Dietary Supplement: Coconut oil + MCT
Dietary Supplement: MCT
Dietary Supplement: Tricaprin
Dietary Supplement: Tricaprylin

Study type

Interventional

Funder types

Other

Identifiers

NCT02679222
2016-541

Details and patient eligibility

About

The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults. Each oil are evaluated individually or in combination over a 8h-period during which repeated blood sampling is performed.

Full description

The study is composed of eight successive visits. Each visit consists of the consumption of one individual oil or a mixture of oils (20 g of coconut oil or 10 g of coconut oil + 10 g of MCT 60-40 or 20 g MCT 60-40 or 10 g coconut oil + 10 g tricaprylin or 20 g tricaprylin or 10 g coconut oil + 10 g triheptanoate or 20 g triheptanoate) and a 8h follow-up during which repeated blood samples are taken for laboratory analysis (plasma beta-hydroxybutyrate, acetoacetate, glucose, free fatty acids, triglycerides, total cholesterol, lactate and insulin).

Enrollment

10 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy adult over 18 y old.

Exclusion criteria

  • Fasting plasma glucose ≥7.0 mM (diabetics or pre-diabetics);
  • Smoking
  • Clinically-significant gastro-intestinal disease/conditions.
  • Clinically-significant liver disease/dysfunction.
  • Clinically-significant cardiac disease/conditions.
  • Clinically-significant abnormal coagulation.
  • Taking a medication that could affect lipid and glucose metabolism
  • Hypertension
  • Pregnancy or breastfeeding
  • Exercising more than 3 times a week

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

10 participants in 1 patient group

Supplementation
Experimental group
Description:
Protocol involved seven separate but identical metabolic study days for each participant. the test substances were evaluated in random order: vehicle (Control) or 20 mL of the test oils (Coconut oil; tricaprin; tricaprylin; MCT [tricaprylin/tricaprin]; coconut oil + MCT [50:50]; Coconut oil + tricaprylin [50:50]) taken twice, once at breakfast and once at mid-day.
Treatment:
Dietary Supplement: Tricaprylin
Dietary Supplement: Tricaprin
Dietary Supplement: MCT
Dietary Supplement: Coconut oil + MCT
Dietary Supplement: Coconut oil
Dietary Supplement: Coconut oil + tricaprylin
Dietary Supplement: Control

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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