Comparing the Ketogenic Effect of Coconut Oil and Different MCTs (MCT-Coco)

Université de Sherbrooke

Status: Completed

Conditions: Healthy Adults

Treatments: Dietary Supplement: Control; Dietary Supplement: Coconut oil + tricaprylin; Dietary Supplement: Coconut oil; Dietary Supplement: Coconut oil + MCT; Dietary Supplement: MCT; Dietary Supplement: Tricaprin; Dietary Supplement: Tricaprylin

Study type: Interventional

Funder types: Other

Identifiers

NCT02679222

2016-541

Details and patient eligibility

About

The aim of this study is to compare the ketogenic effect of coconut oil and three MCT oils (60-40 , tricaprylin and triheptanoate) on the production of ketones in healthy adults. Each oil are evaluated individually or in combination over a 8h-period during which repeated blood sampling is performed.

Full description

The study is composed of eight successive visits. Each visit consists of the consumption of one individual oil or a mixture of oils (20 g of coconut oil or 10 g of coconut oil + 10 g of MCT 60-40 or 20 g MCT 60-40 or 10 g coconut oil + 10 g tricaprylin or 20 g tricaprylin or 10 g coconut oil + 10 g triheptanoate or 20 g triheptanoate) and a 8h follow-up during which repeated blood samples are taken for laboratory analysis (plasma beta-hydroxybutyrate, acetoacetate, glucose, free fatty acids, triglycerides, total cholesterol, lactate and insulin).

Enrollment: 10 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adult over 18 y old.

Exclusion criteria

• Fasting plasma glucose ≥7.0 mM (diabetics or pre-diabetics);
• Smoking
• Clinically-significant gastro-intestinal disease/conditions.
• Clinically-significant liver disease/dysfunction.
• Clinically-significant cardiac disease/conditions.
• Clinically-significant abnormal coagulation.
• Taking a medication that could affect lipid and glucose metabolism
• Hypertension
• Pregnancy or breastfeeding
• Exercising more than 3 times a week

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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10 participants in 1 patient group

Supplementation

Experimental group

Description:

Protocol involved seven separate but identical metabolic study days for each participant. the test substances were evaluated in random order: vehicle (Control) or 20 mL of the test oils (Coconut oil; tricaprin; tricaprylin; MCT [tricaprylin/tricaprin]; coconut oil + MCT [50:50]; Coconut oil + tricaprylin [50:50]) taken twice, once at breakfast and once at mid-day.

Treatment:

Dietary Supplement: Tricaprylin

Dietary Supplement: Tricaprin

Dietary Supplement: MCT

Dietary Supplement: Coconut oil + MCT

Dietary Supplement: Coconut oil

Dietary Supplement: Coconut oil + tricaprylin

Dietary Supplement: Control