Comparing the Use of Vitamin c (Ascorbic Acid) in Eye Burn in Subconjunctival Injection to Topical or Oral Treatment.

Baruch Padeh Medical Center

Status and phase: Withdrawn; Phase 1

Conditions: Burn

Treatments: Dietary Supplement: vitamin c

Study type: Interventional

Funder types: Other

Identifiers

NCT00734695

vitcbrn.CTIL

Details and patient eligibility

About

Eye burns may cause a severe permanent damage. One kind of treatment is the use of vitamin C (Ascorbic acid). This study will compare between subconjunctival topical and/or systemic route of administration and topical and/or systemic administration.

Full description

In order to prevent permanent and severe damage to the eye after eye burn early treatment is mandatory. It is well known and published that the use of Vitamin c may contribute to the healing process of such burns, including burns from chemicals or heat. We believe that the route pf administration of the medicine is as important as the kind of medicine and that subconjunctival injection will have better effect and will influence in a favorable manner on the the end result as well as on the time of the healing.

In order to be able to compare between cases we made a new definition of the severity of the burn according to the extension of the damage on the cornea, conjunctiva and limbus, and according to the severity and depth of the ischemia.

In 3 medical centers 3 protocols of treatment and followup will be compared while only in Baruch Pade Medical Center the main route of administration will be subconjunctival on top of the topical treatment.

Enrollment: 20 estimated patients

Sex: All

Ages: Under 90 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Eyes clinic patients presented with acute chemical or thermal burn.

Exclusion Criteria:other disease

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

20 participants in 3 patient groups

1

Experimental group

Description:

Baruch Pade Medical Center

Treatment:

Dietary Supplement: vitamin c

Dietary Supplement: vitamin c

Dietary Supplement: vitamin c

2

Active Comparator group

Description:

Rambam Medical Center

Treatment:

Dietary Supplement: vitamin c

Dietary Supplement: vitamin c

Dietary Supplement: vitamin c

3

Active Comparator group

Description:

Soroka Medical Center

Treatment:

Dietary Supplement: vitamin c

Dietary Supplement: vitamin c

Dietary Supplement: vitamin c